Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Compromised MAPK signaling in human diseases: an update

Authors
Kim, Eun KyungChoi, Eui-Ju
Issue Date
6월-2015
Publisher
SPRINGER HEIDELBERG
Keywords
Mitogen-activated protein kinase (MAPK); c-Jun NH2-terminal kinase (JNK); p38 MAPK; Extracellular signal-regulated kinase (ERK); Neurodegenerative disease; Cancer
Citation
ARCHIVES OF TOXICOLOGY, v.89, no.6, pp.867 - 882
Indexed
SCIE
SCOPUS
Journal Title
ARCHIVES OF TOXICOLOGY
Volume
89
Number
6
Start Page
867
End Page
882
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/93481
DOI
10.1007/s00204-015-1472-2
ISSN
0340-5761
Abstract
The mitogen-activated protein kinases (MAPKs) in mammals include c-Jun NH2-terminal kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK). These enzymes are serine-threonine protein kinases that regulate various cellular activities including proliferation, differentiation, apoptosis or survival, inflammation, and innate immunity. The compromised MAPK signaling pathways contribute to the pathology of diverse human diseases including cancer and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The JNK and p38 MAPK signaling pathways are activated by various types of cellular stress such as oxidative, genotoxic, and osmotic stress as well as by proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin 1 beta. The Ras-Raf-MEK-ERK signaling pathway plays a key role in cancer development through the stimulation of cell proliferation and metastasis. The p38 MAPK pathway contributes to neuroinflammation mediated by glial cells including microglia and astrocytes, and it has also been associated with anticancer drug resistance in colon and liver cancer. We here summarize recent research on the roles of MAPK signaling pathways in human diseases, with a focus on cancer and neurodegenerative conditions.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Life Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE