Annealed Random Copolymer Model of the B-Z Transition in DNA: Torsional Responses
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Ah-Young | - |
dc.contributor.author | Lee, Nam-Kyung | - |
dc.contributor.author | Hong, Seok-Cheol | - |
dc.contributor.author | Fierling, Julien | - |
dc.contributor.author | Johner, Albert | - |
dc.date.accessioned | 2021-09-04T16:03:16Z | - |
dc.date.available | 2021-09-04T16:03:16Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05-19 | - |
dc.identifier.issn | 0006-3495 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93536 | - |
dc.description.abstract | Both in vivo and in vitro, specific sequences in double-stranded DNA can adopt the left-handed Z-form when underwound. Recently, the B-Z transition of DNA has been studied in detail in magnetic tweezers experiments by several groups. We present a theoretical description of this transition, based on an annealed random copolymer model. The transition of a switchable sequence is discussed as a function of energetic and geometric parameters of the B- and Z-forms, of the applied boundary conditions, and of the characteristics of the B-Z interface. We address a possible torsional softening upon the B-Z transition. The model can be also applied to other biofilaments with annealed torsional/flexural degrees of freedom. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | TORQUE MEASUREMENTS | - |
dc.subject | SUPERHELICAL DNA | - |
dc.subject | REVEALS | - |
dc.subject | TENSION | - |
dc.subject | BINDING | - |
dc.subject | FORM | - |
dc.title | Annealed Random Copolymer Model of the B-Z Transition in DNA: Torsional Responses | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hong, Seok-Cheol | - |
dc.identifier.doi | 10.1016/j.bpj.2015.03.060 | - |
dc.identifier.scopusid | 2-s2.0-84929989715 | - |
dc.identifier.wosid | 000354827200016 | - |
dc.identifier.bibliographicCitation | BIOPHYSICAL JOURNAL, v.108, no.10, pp.2562 - 2572 | - |
dc.relation.isPartOf | BIOPHYSICAL JOURNAL | - |
dc.citation.title | BIOPHYSICAL JOURNAL | - |
dc.citation.volume | 108 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2562 | - |
dc.citation.endPage | 2572 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | TORQUE MEASUREMENTS | - |
dc.subject.keywordPlus | SUPERHELICAL DNA | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | TENSION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | FORM | - |
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