Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cheong, Woo-Chang | - |
dc.contributor.author | Kang, Hye-Ri | - |
dc.contributor.author | Yoon, Hyunyee | - |
dc.contributor.author | Kang, Suk-Jo | - |
dc.contributor.author | Ting, Jenny P. -Y. | - |
dc.contributor.author | Song, Moon Jung | - |
dc.date.accessioned | 2021-09-04T16:04:40Z | - |
dc.date.available | 2021-09-04T16:04:40Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05-15 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93548 | - |
dc.description.abstract | The inflammasome is a molecular platform that stimulates the activation of caspase-1 and the processing of pro-interleukin (IL)-1 beta and pro-IL-18 for secretion. The NOD-like receptor family, pyrin domain containing 3 (NLRP3) protein is activated by diverse molecules and pathogens, leading to the formation of the NLRP3 inflammasome. Recent studies showed that the NLRP3 inflammasome mediates innate immunity against influenza A virus (IAV) infection. In this study, we investigated the function of the IAV non-structural protein 1 (NS1) in the modulation of NLRP3 inflammasome. We found that NS1 proteins derived from both highly pathogenic and low pathogenic strains efficiently decreased secretion of IL-1 alpha and IL-18 from THP-1 cells treated with LPS and ATP. NS1 overexpression significantly impaired the transcription of proinflammatory cytokines by inhibiting transactivation of the nuclear factor-kappa B (NF-kappa B), a major transcription activator. Furthermore, NS1 physically interacted with endogenous NLRP3 and activation of the NLRP3 inflammasome was abrogated in NS1-expressing THP-1 cells. These findings suggest that NS1 downregulates NLRP3 inflammasome activation by targeting NLRP3 as well as NF-kappa B, leading to a reduction in the levels of inflammatory cytokines as a viral immune evasion strategy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | PRE-MESSENGER-RNAS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | ADAPTIVE IMMUNITY | - |
dc.subject | HUMAN MACROPHAGES | - |
dc.subject | NUCLEAR EXPORT | - |
dc.subject | CELL-DEATH | - |
dc.subject | IN-VIVO | - |
dc.subject | INTERFERON | - |
dc.subject | INNATE | - |
dc.subject | GENE | - |
dc.title | Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Moon Jung | - |
dc.identifier.doi | 10.1371/journal.pone.0126456 | - |
dc.identifier.scopusid | 2-s2.0-84929346755 | - |
dc.identifier.wosid | 000354916100069 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.10, no.5 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | PRE-MESSENGER-RNAS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ADAPTIVE IMMUNITY | - |
dc.subject.keywordPlus | HUMAN MACROPHAGES | - |
dc.subject.keywordPlus | NUCLEAR EXPORT | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INTERFERON | - |
dc.subject.keywordPlus | INNATE | - |
dc.subject.keywordPlus | GENE | - |
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