Association between Several Persistent Organic Pollutants and Thyroid Hormone Levels in Cord Blood Serum and Bloodspot of the Newborn Infants of Korea
DC Field | Value | Language |
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dc.contributor.author | Kim, Sunmi | - |
dc.contributor.author | Park, Jeongim | - |
dc.contributor.author | Kim, Hai-Joong | - |
dc.contributor.author | Lee, Jeong Jae | - |
dc.contributor.author | Choi, Gyuyeon | - |
dc.contributor.author | Choi, Sooran | - |
dc.contributor.author | Kim, Sungjoo | - |
dc.contributor.author | Kim, Su Young | - |
dc.contributor.author | Moon, Hyo-Bang | - |
dc.contributor.author | Kim, Sungkyoon | - |
dc.contributor.author | Choi, Kyungho | - |
dc.date.accessioned | 2021-09-04T16:10:25Z | - |
dc.date.available | 2021-09-04T16:10:25Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93564 | - |
dc.description.abstract | Current knowledge on adverse endocrine disruption effects of persistent organic pollutants (POPs) among newborn infants is limited and often controversial. To investigate the associations between prenatal exposure to major POPs and thyroid hormone levels among newborn infants, both cord serum or maternal serum concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs) were compared with five thyroid hormones in cord serum of newborn infants as well as TSH in bloodspot collected at 2 day after birth (n= 104). Since cord serum thyroid hormones could be affected by those of mothers, thyroid hormone concentrations of the matching mothers at delivery were adjusted. In cord serum, BDE-47, -99, and Sigma chlordane (CHD) showed significant positive associations with cord or bloodspot TSH. At the same time, p, p'-dichlorodiphenyldichloroethylene (p, p'-DDE) and hexachlorbenzene (HCB) showed negative associations with total T3 and total T4 in cord serum, respectively. Maternal exposure to beta-hexachlorhexane (beta-HCH), SCHD, SDDT, or p, p'-DDE were also associated with neonatal thyroid hormones. Although the sample size is small and the thyroid hormone levels of the subjects were within the reference range, our observation supports thyroid disrupting potential of several POPs among newborn infants, at the levels occurring in the general population. Considering the importance of thyroid hormones during gestation and early life stages, health implication of thyroid hormone effects by low level POPs exposure deserves further follow up investigations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | POLYBROMINATED DIPHENYL ETHERS | - |
dc.subject | POLYCHLORINATED-BIPHENYLS PCBS | - |
dc.subject | ENDOCRINE-DISRUPTING CHEMICALS | - |
dc.subject | BROMINATED FLAME RETARDANTS | - |
dc.subject | TIME-COURSE VARIATION | - |
dc.subject | SPRAGUE-DAWLEY RATS | - |
dc.subject | HUMAN BREAST-MILK | - |
dc.subject | STIMULATING HORMONE | - |
dc.subject | ORGANOCHLORINE COMPOUNDS | - |
dc.subject | PRENATAL EXPOSURE | - |
dc.title | Association between Several Persistent Organic Pollutants and Thyroid Hormone Levels in Cord Blood Serum and Bloodspot of the Newborn Infants of Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hai-Joong | - |
dc.identifier.doi | 10.1371/journal.pone.0125213 | - |
dc.identifier.scopusid | 2-s2.0-84930677845 | - |
dc.identifier.wosid | 000354543500012 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.10, no.5 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | POLYBROMINATED DIPHENYL ETHERS | - |
dc.subject.keywordPlus | POLYCHLORINATED-BIPHENYLS PCBS | - |
dc.subject.keywordPlus | ENDOCRINE-DISRUPTING CHEMICALS | - |
dc.subject.keywordPlus | BROMINATED FLAME RETARDANTS | - |
dc.subject.keywordPlus | TIME-COURSE VARIATION | - |
dc.subject.keywordPlus | SPRAGUE-DAWLEY RATS | - |
dc.subject.keywordPlus | HUMAN BREAST-MILK | - |
dc.subject.keywordPlus | STIMULATING HORMONE | - |
dc.subject.keywordPlus | ORGANOCHLORINE COMPOUNDS | - |
dc.subject.keywordPlus | PRENATAL EXPOSURE | - |
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