Immune Reconstitution Kinetics following Intentionally Induced Mixed Chimerism by Nonmyeloablative Transplantation
DC Field | Value | Language |
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dc.contributor.author | Kim, Nayoun | - |
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Shin, Junghoon | - |
dc.contributor.author | Nam, Young-Sun | - |
dc.contributor.author | Im, Keon-Il | - |
dc.contributor.author | Lim, Jung-Yeon | - |
dc.contributor.author | Lee, Eun-Sol | - |
dc.contributor.author | Kang, Young-Nam | - |
dc.contributor.author | Park, Se-Ho | - |
dc.contributor.author | Cho, Seok-Goo | - |
dc.date.accessioned | 2021-09-04T16:10:55Z | - |
dc.date.available | 2021-09-04T16:10:55Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05-11 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93567 | - |
dc.description.abstract | Establishing mixed chimerism is a promising approach for inducing donor-specific transplant tolerance. The establishment and maintenance of mixed chimerism may enable long-term engraftment of organ transplants while minimizing the use of immunosuppressants. Several protocols for inducing mixed chimerism have been reported; however, the exact mechanism underlying the development of immune tolerance remains to be elucidated. Therefore, understanding the kinetics of engraftment during early post-transplant period may provide insight into establishing long-term mixed chimerism and permanent transplant tolerance. In this study, we intentionally induced allogeneic mixed chimerism using a nonmyeloablative regimen by host natural killer (NK) cell depletion and T cell-depleted bone marrow (BM) grafts in a major histocompatibility complex (MHC)-mismatched murine model and analyzed the kinetics of donor (C57BL/6) and recipient (BALB/c) engraftment in the weeks following transplantation. Donor BM cells were well engrafted and stabilized without graft-versus-host disease (GVHD) as early as one week post-bone marrow transplantation (BMT). Donor-derived thymic T cells were reconstituted four weeks after BMT; however, the emergence of newly developed T cells was more obvious at the periphery as early as two weeks after BMT. Also, the emergence and changes in ratio of recipient-and donor-derived NKT cells and antigen presenting cells (APCs) including dendritic cells (DCs) and B cells were noted after BMT. Here, we report a longitudinal analysis of the development of donor- and recipient-originated hematopoietic cells in various lymphatic tissues of intentionally induced mixed chimerism mouse model during early post-transplant period. Through the understanding of immune reconstitution at early time points after nonmyeloablative BMT, we suggest guidelines on intentionally inducing durable mixed chimerism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | BONE-MARROW-TRANSPLANTATION | - |
dc.subject | STEM-CELL TRANSPLANTATION | - |
dc.subject | DONOR LIVER-TRANSPLANTATION | - |
dc.subject | RENAL-ALLOGRAFT RECIPIENTS | - |
dc.subject | TOTAL-BODY IRRADIATION | - |
dc.subject | T-CELL | - |
dc.subject | LYMPHOHEMATOPOIETIC CHIMERISM | - |
dc.subject | TOLERANCE INDUCTION | - |
dc.subject | MULTIPLE-MYELOMA | - |
dc.subject | KIDNEY ALLOGRAFT | - |
dc.title | Immune Reconstitution Kinetics following Intentionally Induced Mixed Chimerism by Nonmyeloablative Transplantation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Se-Ho | - |
dc.identifier.doi | 10.1371/journal.pone.0126318 | - |
dc.identifier.scopusid | 2-s2.0-84930631555 | - |
dc.identifier.wosid | 000354542500088 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.10, no.5 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | BONE-MARROW-TRANSPLANTATION | - |
dc.subject.keywordPlus | STEM-CELL TRANSPLANTATION | - |
dc.subject.keywordPlus | DONOR LIVER-TRANSPLANTATION | - |
dc.subject.keywordPlus | RENAL-ALLOGRAFT RECIPIENTS | - |
dc.subject.keywordPlus | TOTAL-BODY IRRADIATION | - |
dc.subject.keywordPlus | T-CELL | - |
dc.subject.keywordPlus | LYMPHOHEMATOPOIETIC CHIMERISM | - |
dc.subject.keywordPlus | TOLERANCE INDUCTION | - |
dc.subject.keywordPlus | MULTIPLE-MYELOMA | - |
dc.subject.keywordPlus | KIDNEY ALLOGRAFT | - |
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