Long-term effects of ischemic postconditioning on clinical outcomes: 1-year follow-up of the POST randomized trial
DC Field | Value | Language |
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dc.contributor.author | Hahn, Joo-Yong | - |
dc.contributor.author | Yu, Cheol Woong | - |
dc.contributor.author | Park, Hun Sik | - |
dc.contributor.author | Song, Young Bin | - |
dc.contributor.author | Kim, Eun Kyoung | - |
dc.contributor.author | Lee, Hyun Jong | - |
dc.contributor.author | Bae, Jang-Whan | - |
dc.contributor.author | Chung, Woo-Young | - |
dc.contributor.author | Choi, Seung-Hyuk | - |
dc.contributor.author | Choi, Jin-Ho | - |
dc.contributor.author | Bae, Jang-Ho | - |
dc.contributor.author | An, Kyung Joo | - |
dc.contributor.author | Park, Jong-Seon | - |
dc.contributor.author | Oh, Ju Hyeon | - |
dc.contributor.author | Kim, Sang-Wook | - |
dc.contributor.author | Hwang, Jin-Yong | - |
dc.contributor.author | Ryu, Jae Kean | - |
dc.contributor.author | Lim, Do-Sun | - |
dc.contributor.author | Gwon, Hyeon-Cheol | - |
dc.date.accessioned | 2021-09-04T16:20:59Z | - |
dc.date.available | 2021-09-04T16:20:59Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0002-8703 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93637 | - |
dc.description.abstract | Background In the Effects of Postconditioning on Myocardial Reperfusion in Patients with ST-segment Elevation Myocardial Infarction (POST) trial, ischemic postconditioning failed to improve myocardial reperfusion. However, long-term effects of ischemic postconditioning on clinical outcomes are not known in patients with ST-segment elevation myocardial infarction. Methods A total of 700 patients undergoing primary percutaneous coronary intervention (PCI) were randomly assigned to the postconditioning group or the conventional primary PCI group in a 1: 1 ratio. Postconditioning was performed immediately after restoration of coronary flow by balloon occlusion 4 times for 1 minute. Complete follow-up data for major clinical events at 1 year were available in 695 patients (99.3%), and analyses were done by the intention to treat principle. The primary outcome was a composite of death, myocardial infarction, severe heart failure, or stent thrombosis at 1 year. Results At 1 year, a composite of death, myocardial infarction, severe heart failure, or stent thrombosis occurred in 21 patients (6.1%) in the postconditioning group and 16 patients (4.6%) in the conventional PCI group (hazard ratio [HR] 1.32, 95% CI 0.69-2.53, P = .40). The risk of death (4.9% vs 3.7%, HR 1.32, 95% CI 0.64-2.71, P = .46), heart failure (2.6% vs 2.3%, HR 1.13, 95% CI 0.44-2.94, P = .80), and stent thrombosis (2.3% vs 1.7%, HR 1.34, 95% CI 0.46-3.85, P = .59) did not differ significantly between the 2 groups. Conclusions Ischemic postconditioning does not seem to improve the 1-year clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.subject | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject | ST-SEGMENT ELEVATION | - |
dc.subject | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject | REPERFUSION | - |
dc.subject | SIZE | - |
dc.subject | INHIBITION | - |
dc.subject | ASPIRATION | - |
dc.subject | RESOLUTION | - |
dc.subject | ABCIXIMAB | - |
dc.subject | THERAPY | - |
dc.title | Long-term effects of ischemic postconditioning on clinical outcomes: 1-year follow-up of the POST randomized trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yu, Cheol Woong | - |
dc.contributor.affiliatedAuthor | Lim, Do-Sun | - |
dc.identifier.doi | 10.1016/j.ahj.2015.01.015 | - |
dc.identifier.scopusid | 2-s2.0-84929262060 | - |
dc.identifier.wosid | 000354172400010 | - |
dc.identifier.bibliographicCitation | AMERICAN HEART JOURNAL, v.169, no.5, pp.639 - 646 | - |
dc.relation.isPartOf | AMERICAN HEART JOURNAL | - |
dc.citation.title | AMERICAN HEART JOURNAL | - |
dc.citation.volume | 169 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 639 | - |
dc.citation.endPage | 646 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | ST-SEGMENT ELEVATION | - |
dc.subject.keywordPlus | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | REPERFUSION | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ASPIRATION | - |
dc.subject.keywordPlus | RESOLUTION | - |
dc.subject.keywordPlus | ABCIXIMAB | - |
dc.subject.keywordPlus | THERAPY | - |
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