Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyung Sook | - |
dc.contributor.author | Ryu, Hwa Sun | - |
dc.contributor.author | Kim, Ji Sung | - |
dc.contributor.author | Kim, Yong Guk | - |
dc.contributor.author | Lee, Hong Kyung | - |
dc.contributor.author | Jung, Jae Kyung | - |
dc.contributor.author | Kwak, Young Shin | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Seo, Seung Yong | - |
dc.contributor.author | Yun, Jieun | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.contributor.author | Hong, Jin Tae | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.contributor.author | Han, Sang-Bae | - |
dc.date.accessioned | 2021-09-04T16:24:23Z | - |
dc.date.available | 2021-09-04T16:24:23Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93663 | - |
dc.description.abstract | 4-O-methylhonokiol (MH) is known to inhibit inflammation by partially understood mechanisms. Here, the anti-inflammatory mechanisms of MH were examined using enzymatic, cellular, and animal assays. In enzymatic assays, MH inhibited COX-2 activity with an IC50 of 0.062 mu M, and also COX-1 with an IC50 of 2.4 mu M. In cellular assays, MH was immunotoxic above 10 mu M. At non-toxic concentrations (below 3 mu M), MH strongly inhibited COX-2-mediated prostaglandin production with an IC50 of 0.1 mu M, whereas did not or slightly affect other functions of B cells, T cells, dendritic cells, and macrophages. In an animal model, MH inhibited the increase in footpad thickness and popliteal lymph node weight in zymosan-injected mice. When analyzed the draining pLNs of zymosan-injected mice on day 5, MH inhibited the overall inflammatory responses. However, MH inhibited cyclooxygenase (COX)-2-mediated prostaglandin production without affecting tumor necrosis factor-a production in inflamed tissues within 6 h after zymosan injection. In summary, our data suggest that COX-2 may be a direct anti-inflammatory target of MH in vitro and in vivo. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | CANNABINOID CB2 RECEPTOR | - |
dc.subject | MEMORY IMPAIRMENT | - |
dc.subject | P21-MEDIATED SUPPRESSION | - |
dc.subject | MAGNOLIA-OFFICINALIS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | TNF-ALPHA | - |
dc.subject | INHIBITION | - |
dc.title | Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwak, Young Shin | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.identifier.doi | 10.1007/s12272-014-0456-8 | - |
dc.identifier.scopusid | 2-s2.0-84939889236 | - |
dc.identifier.wosid | 000354299800029 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.38, no.5, pp.813 - 825 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 38 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 813 | - |
dc.citation.endPage | 825 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001991027 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CANNABINOID CB2 RECEPTOR | - |
dc.subject.keywordPlus | MEMORY IMPAIRMENT | - |
dc.subject.keywordPlus | P21-MEDIATED SUPPRESSION | - |
dc.subject.keywordPlus | MAGNOLIA-OFFICINALIS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | 4-O-methylhonokiol | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Anti-inflammatory target | - |
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