Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.date.accessioned | 2021-09-04T16:25:35Z | - |
dc.date.available | 2021-09-04T16:25:35Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93672 | - |
dc.description.abstract | The aim of this study was to determine whether the functional integrin-alpha-M (ITGAM) rs1143679 polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), lupus nephritis (LN), and rheumatoid arthritis (RA). A series of meta-analyses were conducted to test for associations between the ITGAM rs1143679 polymorphism and SLE, LN, or RA. A total of 24 comparisons involving 7,738 patients and 8,309 controls for SLE, and 2,663 patients and 2,694 controls in RA were considered. Meta-analysis showed a significant association between the ITGAM rs1143679 A allele and SLE in all subjects (OR 1.773, 95 % CI 1.656, 1.901, p < 1.0 x 10(-9)). After stratification by ethnicity, the A allele was found to be significantly associated with SLE in European, Latin American, and Asian. A significant association was also found between the ITGAM A allele and lupus nephritis in Europeans (OR 2.131, 95 % CI 1.565, 2.903, p = 1.6 x 10(-7)). However, no association was found between RA and the ITGAM rs1143679 polymorphism. Our meta-analyses confirm that the ITGAM rs1143679 polymorphism is associated with SLE susceptibility in different ethnic groups and demonstrate that the polymorphism is associated with LN in European. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | GENETIC SUSCEPTIBILITY LOCI | - |
dc.subject | GENOME SCAN METAANALYSIS | - |
dc.subject | DISEASE SUSCEPTIBILITY | - |
dc.subject | VARIANT | - |
dc.subject | CD11B | - |
dc.subject | R77H | - |
dc.subject | REPLICATION | - |
dc.subject | POPULATION | - |
dc.subject | SLE | - |
dc.title | Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1007/s00296-014-3156-2 | - |
dc.identifier.scopusid | 2-s2.0-84928801648 | - |
dc.identifier.wosid | 000353354800004 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, v.35, no.5, pp.815 - 823 | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.title | RHEUMATOLOGY INTERNATIONAL | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 815 | - |
dc.citation.endPage | 823 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | GENETIC SUSCEPTIBILITY LOCI | - |
dc.subject.keywordPlus | GENOME SCAN METAANALYSIS | - |
dc.subject.keywordPlus | DISEASE SUSCEPTIBILITY | - |
dc.subject.keywordPlus | VARIANT | - |
dc.subject.keywordPlus | CD11B | - |
dc.subject.keywordPlus | R77H | - |
dc.subject.keywordPlus | REPLICATION | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | SLE | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | ITGAM | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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