Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients
DC Field | Value | Language |
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dc.contributor.author | Song, Tae-Jin | - |
dc.contributor.author | Chang, Yoonkyung | - |
dc.contributor.author | Shin, Min-Jeong | - |
dc.contributor.author | Heo, Ji Hoe | - |
dc.contributor.author | Kim, Yong-Jae | - |
dc.date.accessioned | 2021-09-04T16:27:49Z | - |
dc.date.available | 2021-09-04T16:27:49Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93690 | - |
dc.description.abstract | Cerebral small vessel diseases (SVDs) are related to stroke or cognitive dysfunction. n-3-polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) represent possible disease-modifying factors for cardiovascular disease or dementia. Our hypothesis was that a low proportion of plasma FAs would be associated with cerebral SVDs. We prospectively enrolled 220 patients with a first-episode cerebral infarction within 7 days after symptom onset. The composition of plasma FAs was analyzed by gas chromatography methods. The presence and burden of cerebral microbleeds (CMBs), high-grade white matter changes (HWCs), high-grade perivascular spaces (HPVSs), and asymptomatic lacunar infarctions (ALIs) were investigated. The mean proportion (+/- SD) was 2.0 +/- 0.7 for EPA, 8.9 +/- 1.5 for DHA, and 12.0 +/- 2.1 for Sigma n-3-PUFAs. In total, 46 (20.9%) patients had CMBs, 64 (29.1 %) had HWCs, 57 (25.9%) had HPVSs, and 65 (29.5%) had ALIs. In univariate analyses, CMBs, HWCs, and HPVSs were each negatively correlated with the proportion of EPA, DHA, and Sigma n-3-PUFAs. In the multivariate analysis, a lower proportion of EPA, DHA and Sigma n-3-PUFAs was associated with the presence of CMBs, HWCs and HPVS, but not ALIs. Total SVDs score was inversely correlated with the proportion of EPA, DHA and Sigma n-3-PUFAs. Overall, we found an association between low proportions of plasma n-3-PUFAs and cerebral SVDs pathologies. Further studies are needed to explore the association and potential therapeutic role of FAs in cerebral SVDs. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | CLINICAL CHARACTERISTICS | - |
dc.subject | ATHEROSCLEROTIC PLAQUES | - |
dc.subject | DOCOSAHEXAENOIC ACID | - |
dc.subject | RISK | - |
dc.subject | MRI | - |
dc.subject | INFLAMMATION | - |
dc.subject | SUBTYPE | - |
dc.title | Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Min-Jeong | - |
dc.identifier.doi | 10.1016/j.nutres.2015.04.008 | - |
dc.identifier.scopusid | 2-s2.0-84929655795 | - |
dc.identifier.wosid | 000355387000002 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH, v.35, no.5, pp.368 - 374 | - |
dc.relation.isPartOf | NUTRITION RESEARCH | - |
dc.citation.title | NUTRITION RESEARCH | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 368 | - |
dc.citation.endPage | 374 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | CLINICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | ATHEROSCLEROTIC PLAQUES | - |
dc.subject.keywordPlus | DOCOSAHEXAENOIC ACID | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | SUBTYPE | - |
dc.subject.keywordAuthor | Small vessel disease | - |
dc.subject.keywordAuthor | Fatty acids composition | - |
dc.subject.keywordAuthor | n-3-polyunsaturated fatty acids | - |
dc.subject.keywordAuthor | Cerebral microbleeds | - |
dc.subject.keywordAuthor | White matter changes | - |
dc.subject.keywordAuthor | Perivascular spaces | - |
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