Role of confirmatory interferon-gamma release assays in school outbreaks of tuberculosis in South Korea
DC Field | Value | Language |
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dc.contributor.author | Kim, H. J. | - |
dc.contributor.author | Lee, G-H | - |
dc.contributor.author | Ryoo, S. | - |
dc.contributor.author | Oh, S-Y. | - |
dc.contributor.author | Lee, J-B. | - |
dc.contributor.author | Kim, J. H. | - |
dc.contributor.author | Shin, C. | - |
dc.contributor.author | Lee, S. H. | - |
dc.date.accessioned | 2021-09-04T16:29:49Z | - |
dc.date.available | 2021-09-04T16:29:49Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1027-3719 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93702 | - |
dc.description.abstract | OBJECTIVE: To investigate the usefulness of confirmatory QuantiFERON (R) (QFT) testing among tuberculin skin test (TST) positive contacts to diagnose latent tuberculous infection (LTBI) in tuberculosis (TB) outbreaks among adolescents. DESIGN: We used the Korean national claims database to identify the development of active TB disease in relation to initial TST (cut-off 10 mm induration) and subsequent QFT results. RESULTS: A total of 7475 contacts in 89 schools were divided into four groups: TST (n=5714), TST+/QFT+ (n = 534), TST+/QFT (n = 697) and TST+ only (n = 530). The mean duration of follow-up was 3.9 +/- 0.9 years. For contacts with no LTBI treatment (n = 6868), TB incidence rates per 1000 person-years (py) and the adjusted hazard ratio (HR) compared with TST-individuals were as follows: TST+/QFT+, 66.2/1000 py (HR 35.59, 95%CI 14.03-90.31, P < 0.001); TST+ only, 10.1/1000 py (HR 5.16, 95%CI 2.91-9.17, P < 0.001); TST+/QFT, 4.0/1000 py (HR 2.05, 95%CI 1.05-4.01, P= 0.035); and TST - 2.0/1000 py. The TB progression rate was significantly higher in TST+/QFT+ than in TST+/QFT individuals (HR 16.82, 95 CI 5.84-48.46, P < 0.001). CONCLUSION: A confirmatory QFT for TST+ contacts could reduce the number of candidates for LTBI treatment after school TB outbreaks. KEY WORDS: latent tuberculous | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | - |
dc.subject | LATENT TUBERCULOSIS | - |
dc.subject | PREDICTIVE-VALUE | - |
dc.subject | INFECTION | - |
dc.subject | CONTACTS | - |
dc.subject | HEALTH | - |
dc.title | Role of confirmatory interferon-gamma release assays in school outbreaks of tuberculosis in South Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, C. | - |
dc.contributor.affiliatedAuthor | Lee, S. H. | - |
dc.identifier.doi | 10.5588/ijtld.14.0636 | - |
dc.identifier.scopusid | 2-s2.0-84928893476 | - |
dc.identifier.wosid | 000353670200015 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.19, no.5, pp.576 - 581 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | - |
dc.citation.volume | 19 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 576 | - |
dc.citation.endPage | 581 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | LATENT TUBERCULOSIS | - |
dc.subject.keywordPlus | PREDICTIVE-VALUE | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | CONTACTS | - |
dc.subject.keywordPlus | HEALTH | - |
dc.subject.keywordAuthor | latent tuberculous infection | - |
dc.subject.keywordAuthor | QuantiFERON test | - |
dc.subject.keywordAuthor | tuberculin skin test | - |
dc.subject.keywordAuthor | TB outbreaks | - |
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