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Functionalized Nanoparticle Probes for Protein Detection

Authors
Park, Do HyunLee, Jae-Seung
Issue Date
5월-2015
Publisher
KOREAN INST METALS MATERIALS
Keywords
nanoparticles; functionalization; antibody; aptamer; protein detection
Citation
ELECTRONIC MATERIALS LETTERS, v.11, no.3, pp.336 - 345
Indexed
SCIE
SCOPUS
KCI
Journal Title
ELECTRONIC MATERIALS LETTERS
Volume
11
Number
3
Start Page
336
End Page
345
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/93713
DOI
10.1007/s13391-014-4383-0
ISSN
1738-8090
Abstract
In this Review, we discuss representative studies of recent advances in the development of nanoparticle-based protein detection methods, with a focus on the properties and functionalization of nanoparticle probes, as well as their use in detection schemes. We have focused on functionalized nanoparticle probes because they offer a number of advantages over conventional assays and because their use for detecting protein targets for diagnostic purposed has been demonstrated. In this report, we discuss nanoparticle probes classified by material type (gold, silver, silica, semiconductor, carbon, and virus) and surface functionality (antibody, aptamer, and DNA), which play a critical role in enhancing the sensitivity, selectivity, and efficiency of the detection systems. In particular, the synergistic function of each component of the nanoparticle probe is emphasized in terms of specific chemical and physical properties. This research area is in its early stages with many milestones to reach before nanoparticle probes are successfully applied in the field; however, the substantial ongoing efforts of researchers underline the great promise offered by nanoparticlebased probes for future applications.
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Lee, Jae Seung
공과대학 (신소재공학부)
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