Additive Beneficial Effects of Valsartan Combined with Rosuvastatin in the Treatment of Hypercholesterolemic Hypertensive Patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Ji-Yong | - |
dc.contributor.author | Lee, Sang-Hak | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.contributor.author | Seo, Hong Seog | - |
dc.contributor.author | Kim, Woo-Shik | - |
dc.contributor.author | Ahn, Youngkeun | - |
dc.contributor.author | Lee, Nae-Hee | - |
dc.contributor.author | Koh, Kwang Kon | - |
dc.contributor.author | Kang, Tae-Soo | - |
dc.contributor.author | Jo, Sang-Ho | - |
dc.contributor.author | Hong, Bum-Kee | - |
dc.contributor.author | Bae, Jang-Ho | - |
dc.contributor.author | Yang, Hyoung-Mo | - |
dc.contributor.author | Cha, Kwang Soo | - |
dc.contributor.author | Kim, Bum Soo | - |
dc.contributor.author | Kwak, Choong Hwan | - |
dc.contributor.author | Cho, Deok-Kyu | - |
dc.contributor.author | Kim, Ung | - |
dc.contributor.author | Zo, Joo-Hee | - |
dc.contributor.author | Kang, Duk-Hyun | - |
dc.contributor.author | Pyun, Wook Bum | - |
dc.contributor.author | Chun, Kook Jin | - |
dc.contributor.author | Namgung, June | - |
dc.contributor.author | Cha, Tae-Joon | - |
dc.contributor.author | Juhn, Jae-Hyeon | - |
dc.contributor.author | Jung, YeiLi | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.date.accessioned | 2021-09-04T16:46:01Z | - |
dc.date.available | 2021-09-04T16:46:01Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93727 | - |
dc.description.abstract | Background and Objectives: We compared the efficacy and safety of valsartan and rosuvastatin combination therapy with each treatment alone in hypercholesterolemic hypertensive patients. Subjects and Methods: Patients who met inclusion criteria were randomized to receive 1 of the following 2-month drug regimens: valsartan 160 mg plus rosuvastatin 20 mg, valsartan 160 mg plus placebo, or rosuvastatin 20 mg plus placebo. The primary efficacy variables were change in sitting diastolic blood pressure (sitDBP) and sitting systolic blood pressure (sitSBP), and percentage change in low-density lipoprotein-cholesterol (LDL-C) in the combination, valsartan, and rosuvastatin groups. Adverse events (AEs) during the study were analyzed. Results: A total of 354 patients were screened and 123 of them were finally randomized. Changes of sitDBP by least squares mean (LSM) were -11.1, -7.2, and -3.6 mm Hg, respectively, and was greater in the combination, as compared to both valsartan (p=0.02) and rosuvastatin (p<0.001). Changes of sitSBP by LSM were -13.2, -10.8, and -4.9 mm Hg, and was greater in the combination, as compared to rosuvastatin (p=0.006) and not valsartan (p=0.42). Percentage changes of LDL-C by LSM were -52, -4, and -47% in each group, and was greater in the combination, as compared to valsartan (p<0.001), similar to rosuvastatin (p=0.16). Most AEs were mild and resolved by the end of the study. Conclusion: Combination treatment with valsartan and rosuvastatin exhibited an additive blood pressure-lowering effect with acceptable tolerability, as compared to valsartan monotherapy. Its lipid lowering effect was similar to rosuvatatin monotherapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC CARDIOLOGY | - |
dc.subject | BLOOD-PRESSURE CONTROL | - |
dc.subject | CHOLESTEROL | - |
dc.subject | COMBINATION | - |
dc.subject | PRAVASTATIN | - |
dc.subject | EFFICACY | - |
dc.subject | AMLODIPINE | - |
dc.subject | LOVASTATIN | - |
dc.subject | INHIBITORS | - |
dc.subject | RECEPTOR | - |
dc.subject | STATINS | - |
dc.title | Additive Beneficial Effects of Valsartan Combined with Rosuvastatin in the Treatment of Hypercholesterolemic Hypertensive Patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Hong Seog | - |
dc.identifier.doi | 10.4070/kcj.2015.45.3.225 | - |
dc.identifier.scopusid | 2-s2.0-84930399492 | - |
dc.identifier.wosid | 000355499600008 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, v.45, no.3, pp.225 - 233 | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.citation.title | KOREAN CIRCULATION JOURNAL | - |
dc.citation.volume | 45 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 225 | - |
dc.citation.endPage | 233 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002013786 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | BLOOD-PRESSURE CONTROL | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | PRAVASTATIN | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | AMLODIPINE | - |
dc.subject.keywordPlus | LOVASTATIN | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | STATINS | - |
dc.subject.keywordAuthor | Valsartan | - |
dc.subject.keywordAuthor | Rosuvastatin | - |
dc.subject.keywordAuthor | Drug therapy | - |
dc.subject.keywordAuthor | combination | - |
dc.subject.keywordAuthor | Controlled clinical trials | - |
dc.subject.keywordAuthor | randomized | - |
dc.subject.keywordAuthor | Blood pressure | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.