Fermented soy bean extract suppresses differentiation of 3T3-L1 preadipocytes and facilitates its glucose utilization
DC Field | Value | Language |
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dc.contributor.author | Hwang, Ji Won | - |
dc.contributor.author | Do, Hyun Ju | - |
dc.contributor.author | Kim, Oh Yoen | - |
dc.contributor.author | Chung, Ji Hyung | - |
dc.contributor.author | Lee, Jae-Yeon | - |
dc.contributor.author | Park, Young Shik | - |
dc.contributor.author | Hwang, Kyo Yeol | - |
dc.contributor.author | Seong, Su-Il | - |
dc.contributor.author | Shin, Min-Jeong | - |
dc.date.accessioned | 2021-09-04T16:46:50Z | - |
dc.date.available | 2021-09-04T16:46:50Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93731 | - |
dc.description.abstract | Obesity is a serious health problem which may continuously increase the morbidity and mortality associated with a variety of acute and chronic diseases. This study aimed to examine the antiobesity effect of soy bean extract fermented by Bacillus subtilis MORI (BTD-1) and to elucidate the mechanisms underlying such effects using 3T3-L1 preadipocytes. Lipid accumulations were significantly inhibited by BTD-1 treatment, which were accompanied by the decreased expression of CCAAT element binding protein alpha (C/EBP alpha) and the increased phosphorylation of acetyl-CoA carboxylase (ACC) protein expression. In addition, BTD-1 treatment increased the expression of glucose transporter 4 (GLUT4) along with significantly increasing glucose uptake into the adipocytes based on results of a 2-deoxy-D-[H-3] glucose uptake assay. Our findings suggest that BTD-1 may suppress the differentiation of 3T3-L1 adipocytes and greatly facilitate glucose uptake into the adipocytes. Therefore, BTD-1 has a potential as a functional food ingredient in improving obesity and related metabolic disorders. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | ANTIOBESITY DRUGS | - |
dc.subject | C/EBP-ALPHA | - |
dc.subject | OBESITY | - |
dc.subject | METABOLISM | - |
dc.subject | IDENTIFICATION | - |
dc.subject | ADIPOGENESIS | - |
dc.subject | CARBOXYLASE | - |
dc.subject | EXPRESSION | - |
dc.subject | QUERCETIN | - |
dc.subject | TRANSPORT | - |
dc.title | Fermented soy bean extract suppresses differentiation of 3T3-L1 preadipocytes and facilitates its glucose utilization | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Min-Jeong | - |
dc.identifier.doi | 10.1016/j.jff.2015.04.002 | - |
dc.identifier.scopusid | 2-s2.0-84929241127 | - |
dc.identifier.wosid | 000355240800049 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.15, pp.516 - 524 | - |
dc.relation.isPartOf | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 15 | - |
dc.citation.startPage | 516 | - |
dc.citation.endPage | 524 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ANTIOBESITY DRUGS | - |
dc.subject.keywordPlus | C/EBP-ALPHA | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.subject.keywordPlus | CARBOXYLASE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordAuthor | Soy bean extract | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | C/EBP alpha | - |
dc.subject.keywordAuthor | ACC | - |
dc.subject.keywordAuthor | GLUT4 | - |
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