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Geranylated Flavanones from Paulownia coreana and Their Inhibitory Effects on Nitric Oxide Production

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dc.contributor.authorJin, Qinghao-
dc.contributor.authorLee, Chul-
dc.contributor.authorLee, Jin Woo-
dc.contributor.authorLee, Dongho-
dc.contributor.authorKim, Youngsoo-
dc.contributor.authorHong, Jin Tae-
dc.contributor.authorKim, Jin Sook-
dc.contributor.authorKim, Joo-Hwan-
dc.contributor.authorLee, Mi Kyeong-
dc.contributor.authorHwang, Bang Yeon-
dc.date.accessioned2021-09-04T16:50:36Z-
dc.date.available2021-09-04T16:50:36Z-
dc.date.created2021-06-18-
dc.date.issued2015-05-
dc.identifier.issn0009-2363-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/93757-
dc.description.abstractThe activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 mu m.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPHARMACEUTICAL SOC JAPAN-
dc.subjectTOMENTOSA FRUITS-
dc.subjectSUBSTITUTED FLAVANONES-
dc.subjectFLAVONOIDS-
dc.subjectDERIVATIVES-
dc.subjectGLYCOSIDES-
dc.titleGeranylated Flavanones from Paulownia coreana and Their Inhibitory Effects on Nitric Oxide Production-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Dongho-
dc.identifier.doi10.1248/cpb.c14-00839-
dc.identifier.scopusid2-s2.0-84929994611-
dc.identifier.wosid000353856000010-
dc.identifier.bibliographicCitationCHEMICAL & PHARMACEUTICAL BULLETIN, v.63, no.5, pp.384 - 387-
dc.relation.isPartOfCHEMICAL & PHARMACEUTICAL BULLETIN-
dc.citation.titleCHEMICAL & PHARMACEUTICAL BULLETIN-
dc.citation.volume63-
dc.citation.number5-
dc.citation.startPage384-
dc.citation.endPage387-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusTOMENTOSA FRUITS-
dc.subject.keywordPlusSUBSTITUTED FLAVANONES-
dc.subject.keywordPlusFLAVONOIDS-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusGLYCOSIDES-
dc.subject.keywordAuthorPaulownia coreana-
dc.subject.keywordAuthorPaulowniaceae-
dc.subject.keywordAuthorgeranylated flavanone-
dc.subject.keywordAuthornitric oxide inhibitor-
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