Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery
DC Field | Value | Language |
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dc.contributor.author | Feng, Chao | - |
dc.contributor.author | Li, Jing | - |
dc.contributor.author | Kong, Ming | - |
dc.contributor.author | Liu, Ya | - |
dc.contributor.author | Cheng, Xiao Jie | - |
dc.contributor.author | Li, Yang | - |
dc.contributor.author | Park, Hyun Jin | - |
dc.contributor.author | Chen, Xi Guang | - |
dc.date.accessioned | 2021-09-04T17:28:14Z | - |
dc.date.available | 2021-09-04T17:28:14Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-04-01 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93870 | - |
dc.description.abstract | To develop more effective anticancer mucoadhesive drug delivery system for the treatment of colorectal cancer, chitosan based nanogels (NGs) were prepared by electrostatic interaction between chitosan (CS) and carboxymethyl-chitosan (CMCS). By respectively using tripolyphosphate (TPP) and CaCl2 as ionic crosslinker, two well-characterized doxorubicin hydrochloride (DOX) loaded NGs with opposite zeta potential (DOX:CS/CMCS/TPP NGs, -32.6 +/- 1.1 mV and DOX:CS/CMCS/Ca2+ NGs, +31.8 +/- 0.9 mV) were obtained. Compared with DOX:CS/CMCS/TPP NGs, DOX:CS/CMCS/Ca2+ NGs were taken up to a greater extent by colorectal cancer cells, resulting in greater reduction in percentage of cell viability. Owing to high binding capability to mucin and inhibited paracellular transport by colon, DOX:CS/CMCS/Ca2+ NGs exhibited improved mucoadhesion and limited permeability. This is beneficial to prolong the contact time of formulation onto intestinal mucosa and improved local drug concentration. The results provided evidence DOX:CS/CMCS/Ca2+ NGs to be exciting and promising for the treatment of colorectal cancer. (C) 2015 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | CELLULAR UPTAKE | - |
dc.subject | COLON-CANCER | - |
dc.subject | NANOPARTICLES | - |
dc.subject | MICROSPHERES | - |
dc.subject | SYSTEMS | - |
dc.subject | 5-FLUOROURACIL | - |
dc.subject | ENHANCEMENT | - |
dc.subject | MECHANISM | - |
dc.title | Surface charge effect on mucoadhesion of chitosan based nanogels for local anti-colorectal cancer drug delivery | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hyun Jin | - |
dc.identifier.doi | 10.1016/j.colsurfb.2015.02.042 | - |
dc.identifier.scopusid | 2-s2.0-84939967882 | - |
dc.identifier.wosid | 000353930000055 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, v.128, pp.439 - 447 | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.title | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.citation.volume | 128 | - |
dc.citation.startPage | 439 | - |
dc.citation.endPage | 447 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | CELLULAR UPTAKE | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | 5-FLUOROURACIL | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | Chitosan | - |
dc.subject.keywordAuthor | Nanogels | - |
dc.subject.keywordAuthor | Cellular uptake | - |
dc.subject.keywordAuthor | Mucoadhesion | - |
dc.subject.keywordAuthor | Colorectal cancer | - |
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