Meta-analysis of associations between functional prolactin-1149 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-04T17:34:21Z | - |
dc.date.available | 2021-09-04T17:34:21Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 0770-3198 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93912 | - |
dc.description.abstract | The aim of this study was to determine whether the prolactin -1149 G/T polymorphism confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted for examining the associations between prolactin -1149 G/T polymorphism and susceptibility to SLE or RA using allele contrast, recessive and dominant models, and homozygote contrast. A total of 10 comparative studies, consisting of 4 SLE and 6 RA studies, involving 4252 patients and 4949 controls, were included in the meta-analysis. No association between the prolactin -1149 G allele and SLE was found when all study subjects were considered together (OR = 1.019, 95 % CI = 1.841-1.236, p = 0.845). Stratification by ethnicity also indicated no association between the prolactin G allele and SLE in either Caucasian or Latin American populations. In contrast, a significant association was observed between the prolactin G allele and RA in all subjects (OR = 1.123, 95 % CI = 1.052-1.198, p = 4.6 x 10(-5)). After stratification by ethnicity, the G allele was found to be significantly associated with RA in Caucasians (OR = 1.112, 95 % CI = 1.041-1.189, p = 0.002). Furthermore, the prolactin -1149 G/T polymorphism was found to be associated with RA in Caucasians under the dominant model and under homozygote contrast. This meta-analysis demonstrates that the prolactin -1149 G/T polymorphism is associated with susceptibility to RA, but not SLE, in Caucasians. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER LONDON LTD | - |
dc.subject | GENOME SCAN METAANALYSIS | - |
dc.subject | PROMOTER POLYMORPHISM | - |
dc.subject | GENE | - |
dc.subject | RESPONSIVENESS | - |
dc.subject | ANTIBODIES | - |
dc.title | Meta-analysis of associations between functional prolactin-1149 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s10067-015-2904-3 | - |
dc.identifier.scopusid | 2-s2.0-84925483582 | - |
dc.identifier.wosid | 000351512800008 | - |
dc.identifier.bibliographicCitation | CLINICAL RHEUMATOLOGY, v.34, no.4, pp.683 - 690 | - |
dc.relation.isPartOf | CLINICAL RHEUMATOLOGY | - |
dc.citation.title | CLINICAL RHEUMATOLOGY | - |
dc.citation.volume | 34 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 683 | - |
dc.citation.endPage | 690 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | GENOME SCAN METAANALYSIS | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | RESPONSIVENESS | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Prolactin | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
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