Ionizing radiation-inducible miR-30e promotes glioma cell invasion through EGFR stabilization by directly targeting CBL-B
DC Field | Value | Language |
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dc.contributor.author | Kwak, Seo-Young | - |
dc.contributor.author | Kim, Bu-Yeon | - |
dc.contributor.author | Ahn, Hyun-Joo | - |
dc.contributor.author | Yoo, Je-Ok | - |
dc.contributor.author | Kim, Joon | - |
dc.contributor.author | Bae, In Hwa | - |
dc.contributor.author | Han, Young-Hoon | - |
dc.date.accessioned | 2021-09-04T17:38:54Z | - |
dc.date.available | 2021-09-04T17:38:54Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1742-464X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/93944 | - |
dc.description.abstract | MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the transcriptional and post-transcriptional levels. Here we show that miR-30e, which was previously identified as an ionizing radiation-inducible miRNA, enhances cellular invasion by promoting secretion of the matrix metalloproteinase MMP-2. The enhancement of cellular invasion by miR-30e involved up-regulation of the epidermal growth factor receptor (EGFR) and subsequent activation of its downstream signaling mediators, AKT and extracellular signal-regulated kinase. EGFR up-regulation by miR-30e occurred due to stabilization of the EGFR protein. The E3 ubiquitin ligase casitas B-lineage lymphomaB (CBL-B) was down-regulated by miR-30e, and this led to increased EGFR abundance. A 3 UTR reporter assay confirmed that CBL-B is a direct target of miR-30e. Knocking down CBL-B expression phenocopied the effects of miR-30e, whereas ectopic expression of CBL-B suppressed miR-30e-induced EGFR up-regulation and invasion. Collectively, our results suggest that targeting miR-30e may limit the invasiveness induced during glioma radiotherapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | GROWTH-FACTOR RECEPTOR | - |
dc.subject | EXPRESSION | - |
dc.subject | MICRORNAS | - |
dc.subject | UBIQUITINATION | - |
dc.subject | PROLIFERATION | - |
dc.subject | GENE | - |
dc.subject | ANTAGONISTS | - |
dc.subject | MIGRATION | - |
dc.subject | BIOLOGY | - |
dc.title | Ionizing radiation-inducible miR-30e promotes glioma cell invasion through EGFR stabilization by directly targeting CBL-B | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.1111/febs.13238 | - |
dc.identifier.scopusid | 2-s2.0-84927636684 | - |
dc.identifier.wosid | 000353659600013 | - |
dc.identifier.bibliographicCitation | FEBS JOURNAL, v.282, no.8, pp.1512 - 1525 | - |
dc.relation.isPartOf | FEBS JOURNAL | - |
dc.citation.title | FEBS JOURNAL | - |
dc.citation.volume | 282 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1512 | - |
dc.citation.endPage | 1525 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MICRORNAS | - |
dc.subject.keywordPlus | UBIQUITINATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | ANTAGONISTS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordAuthor | CBL-B | - |
dc.subject.keywordAuthor | EGFR | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | miR-30e | - |
dc.subject.keywordAuthor | MMP-2 | - |
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