Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Miri | - |
dc.contributor.author | Park, Hyeonji | - |
dc.contributor.author | Jeon, Sea Wha | - |
dc.contributor.author | Bang, JeongKyu | - |
dc.contributor.author | Chung, Ka Young | - |
dc.contributor.author | Choi, Dal Woong | - |
dc.contributor.author | Kim, EunJoo | - |
dc.contributor.author | Lim, Kyung-Min | - |
dc.date.accessioned | 2021-09-04T17:47:59Z | - |
dc.date.available | 2021-09-04T17:47:59Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 0340-3696 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94009 | - |
dc.description.abstract | Diverse compound sources are being explored for de-pigmentation activities to develop novel therapeutic agents or functional cosmetic ingredients for hyper-pigmentation disorders. Peptoids are a class of peptidomimetics whose side chains are appended to the nitrogen atom of the peptide backbone, instead of alpha-carbon. Peptoids are more durable against proteolysis and are being actively investigated in drug discovery, but rarely studied as cosmetic ingredients. Here, we demonstrated that new hexa-peptoids, PAL-10 and PAL-12, can inhibit melanogenesis in B16F10 melanoma cells, a 3D pigmented human skin model (Neoderm(A (R))-ME, Tegoscience Co) and zebrafish. Anti-melanogenic effects of PAL-10 or PAL-12 as compared with arbutin, a positive control in B16F10 cells, Neoderm(A (R))-ME and zebrafish were statistically significant and concentration-dependent anti-melanogenic effects were manifested as determined by image, histology, and melanin contents. Anti-melanogenic effects of PAL-10 appeared to be from enzymatic inhibition of tyrosinase while mRNA expression of melanogenic enzymes was not affected. In conclusion, we demonstrated that PAL-10 and PAL-12 can be used as a new cosmetic ingredient with strong brightening efficacies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | BIOACTIVE OLIGOPEPTIDES | - |
dc.subject | MELANIN SYNTHESIS | - |
dc.subject | PEPTIDE | - |
dc.subject | PEPTOIDS | - |
dc.subject | CELLS | - |
dc.subject | DEPIGMENTATION | - |
dc.subject | INHIBITORS | - |
dc.subject | ZEBRAFISH | - |
dc.subject | DISCOVERY | - |
dc.subject | OLIGOMERS | - |
dc.title | Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Dal Woong | - |
dc.identifier.doi | 10.1007/s00403-015-1555-1 | - |
dc.identifier.scopusid | 2-s2.0-84925536908 | - |
dc.identifier.wosid | 000351401000006 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF DERMATOLOGICAL RESEARCH, v.307, no.3, pp.249 - 257 | - |
dc.relation.isPartOf | ARCHIVES OF DERMATOLOGICAL RESEARCH | - |
dc.citation.title | ARCHIVES OF DERMATOLOGICAL RESEARCH | - |
dc.citation.volume | 307 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 249 | - |
dc.citation.endPage | 257 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | BIOACTIVE OLIGOPEPTIDES | - |
dc.subject.keywordPlus | MELANIN SYNTHESIS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | PEPTOIDS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DEPIGMENTATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | ZEBRAFISH | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | OLIGOMERS | - |
dc.subject.keywordAuthor | Peptoid | - |
dc.subject.keywordAuthor | Melanogenesis | - |
dc.subject.keywordAuthor | Zebrafish | - |
dc.subject.keywordAuthor | 3D human skin models | - |
dc.subject.keywordAuthor | Tyrosinase | - |
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