The Effect of Clonidine Pretreatment on Epidural Resiniferatoxin in a Neuropathic Pain Rat Model
DC Field | Value | Language |
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dc.contributor.author | Lee, Mi Geum | - |
dc.contributor.author | Lee, Dong Kyu | - |
dc.contributor.author | Huh, Billy K. | - |
dc.contributor.author | Choi, Sang Sik | - |
dc.contributor.author | Kim, Hee Zoo | - |
dc.contributor.author | Lim, Byung Gun | - |
dc.contributor.author | Kim, Hong Soon | - |
dc.contributor.author | Choi, Yun Suk | - |
dc.contributor.author | Hur, Won Seok | - |
dc.contributor.author | Lee, Mi Kyoung | - |
dc.date.accessioned | 2021-09-04T17:55:51Z | - |
dc.date.available | 2021-09-04T17:55:51Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 0386-300X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94033 | - |
dc.description.abstract | Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. Using a rat model of neuropathic pain, we evaluated the effect of pretreatment with clonidine which has been shown to relieve intradermal capsaicin-induced hyperalgesia-on the initial hyperalgesic response and the thermal analgesic property of RTX. Thirty-six male rats were divided into 6 treatment groups (n = 6 each): RTX 500 ng, RTX tug, clonidine 20 mu g (Cl), Cl+RTX 500 ng, Cl+RTX mu g, or normal saline 20 mu L (control). We evaluated the short-term (180min) and long-term (20 days) analgesic effects of RTX after thermal stimulation and mechanical stimulation. RTX had significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to the thermal stimulus, but the RTX 500 ng and RTX mu g groups showed no initial short-term thermal hyperalgesic responses when pretreated with clonidine. The Cl+RTX mu g rats' behavior scores indicated that they were more calm and comfortable compared to the RTX 1 mu g rats. Even though we cannot precisely confirm that pretreatment with clonidine potentiates or adds to the analgesic effect of RTX, clonidine pretreatment with epidural RTX eliminated the initial RTX-associated hyperalgesic response and systemic toxicity in this neuropathic pain rat model. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OKAYAMA UNIV MED SCHOOL | - |
dc.subject | INTRATHECAL CLONIDINE | - |
dc.subject | ANALGESIA | - |
dc.subject | CAPSAICIN | - |
dc.subject | ALLODYNIA | - |
dc.title | The Effect of Clonidine Pretreatment on Epidural Resiniferatoxin in a Neuropathic Pain Rat Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong Kyu | - |
dc.contributor.affiliatedAuthor | Choi, Sang Sik | - |
dc.contributor.affiliatedAuthor | Kim, Hee Zoo | - |
dc.contributor.affiliatedAuthor | Lim, Byung Gun | - |
dc.contributor.affiliatedAuthor | Lee, Mi Kyoung | - |
dc.identifier.scopusid | 2-s2.0-84946174893 | - |
dc.identifier.wosid | 000353181700004 | - |
dc.identifier.bibliographicCitation | ACTA MEDICA OKAYAMA, v.69, no.2, pp.95 - 103 | - |
dc.relation.isPartOf | ACTA MEDICA OKAYAMA | - |
dc.citation.title | ACTA MEDICA OKAYAMA | - |
dc.citation.volume | 69 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 103 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | INTRATHECAL CLONIDINE | - |
dc.subject.keywordPlus | ANALGESIA | - |
dc.subject.keywordPlus | CAPSAICIN | - |
dc.subject.keywordPlus | ALLODYNIA | - |
dc.subject.keywordAuthor | clonidine | - |
dc.subject.keywordAuthor | epidural administration | - |
dc.subject.keywordAuthor | resiniferatoxin | - |
dc.subject.keywordAuthor | spinal nerve ligation rat model | - |
dc.subject.keywordAuthor | thermal hyperalgesia | - |
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