Transmembrane protein 173 inhibits RANKL-induced osteoclast differentiation
DC Field | Value | Language |
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dc.contributor.author | Choe, Chung-Hyeon | - |
dc.contributor.author | Park, In Sun | - |
dc.contributor.author | Park, Jisang | - |
dc.contributor.author | Yu, Kang-Yeol | - |
dc.contributor.author | Jang, Hyonseok | - |
dc.contributor.author | Kim, Ju | - |
dc.contributor.author | Jang, Yong-Suk | - |
dc.date.accessioned | 2021-09-04T18:04:12Z | - |
dc.date.available | 2021-09-04T18:04:12Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2015-03-24 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94095 | - |
dc.description.abstract | Tmem173 was identified as a growth inhibitor associated with major histocompatibility complex (MHC) class II and a potential stimulator for IFN-beta, an innate immune inducer and a negative feedback controller for RANKL-induced osteoclast differentiation of monocytic macrophage cells. In this study, we confirmed that transmembrane protein 173 (Tmem173) overexpression inhibited the expression of osteoclast-specific genes, tartrate-resistant acid phosphatase (TRAP), cathepsin K, and matrix metalloproteinase-9 (MMP-9), as well as bone resorption pit formation in RANKL-treated RAW 264.7 cells. Activation of osteoclast-specific transcription factors, c-Fos and nuclear factor of activated T cells cytoplasmic-1 (NFATc1), and RANKL-induced activation of ERK were also down-regulated by Tmem173 overexpression. Collectively, these results suggest that Tmem173 plays a regulatory role in RANKL-RANK-mediated signaling in osteoclastogenesis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | BONE | - |
dc.subject | OSTEOPOROSIS | - |
dc.subject | ACTIVATION | - |
dc.subject | IMMUNE | - |
dc.subject | ACID | - |
dc.subject | OSTEOIMMUNOLOGY | - |
dc.subject | OSTEOPROTEGERIN | - |
dc.subject | TRANSDUCTION | - |
dc.subject | DENSITY | - |
dc.title | Transmembrane protein 173 inhibits RANKL-induced osteoclast differentiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Hyonseok | - |
dc.identifier.doi | 10.1016/j.febslet.2015.02.018 | - |
dc.identifier.scopusid | 2-s2.0-84924370345 | - |
dc.identifier.wosid | 000351185100007 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.589, no.7, pp.836 - 841 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 589 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 836 | - |
dc.citation.endPage | 841 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | OSTEOPOROSIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | OSTEOIMMUNOLOGY | - |
dc.subject.keywordPlus | OSTEOPROTEGERIN | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | DENSITY | - |
dc.subject.keywordAuthor | Osteoclastogenesis | - |
dc.subject.keywordAuthor | RANK ligand | - |
dc.subject.keywordAuthor | Transmembrane protein 173 | - |
dc.subject.keywordAuthor | Tartrate-resistant acid phosphatase | - |
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