Production of CNT-taxol-embedded PCL microspheres using an ammonium-based room temperature ionic liquid: As a sustained drug delivery system
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seong Yeol | - |
dc.contributor.author | Hwang, Ji-Young | - |
dc.contributor.author | Seo, Jae-Won | - |
dc.contributor.author | Shin, Ueon Sang | - |
dc.date.accessioned | 2021-09-04T18:12:12Z | - |
dc.date.available | 2021-09-04T18:12:12Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-03-15 | - |
dc.identifier.issn | 0021-9797 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94122 | - |
dc.description.abstract | We describe a one-pot method for the mass production of polymeric microspheres containing water-soluble carbon-nanotube (w-CNT)-taxol complexes using an ammonium-based room temperature ionic liquid. Polycaprolactone (PCL), trioctylmethylammonium chloride (TOMAC; liquid state from -20 to 240 degrees C), and taxol were used, respectively, as a model polymer, room temperature ionic liquid, and drug. Large quantities of white colored PCL powder without w-CNT-taxol complexes and gray colored PCL powders containing w-CNT-taxol (1:1 or 1:2 wt/wt) complexes were produced by phase separation between the hydrophilic TOMAC and the hydrophobic PCL. Both microsphere types had a uniform, spherical structure of average diameter 3-5 mu m. The amount of taxol embedded in PCL microspheres was determined by HPLC and H-1 NMR to be 8-12 mu g per 1.0 mg of PCL (loading capacity (LC): 0.8-1.2%; entrapment efficiency (EE): 16-24%). An in vitro HPLC release assay showed sustain release of taxol without an initial burst over 60 days at an average rate of 0.003-0.0073 mg per day. The viability patterns of human breast cancer cells (MCF-7) for PCTx-1 and -2 showed dose-dependent inhibitory effects. In the presence of PCTx-1 and -2, the MCF-7 cells showed high viability in the concentration level of, respectably, <70 and <5 mu g/mL. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | SELF-ASSEMBLED MONOLAYERS | - |
dc.subject | EPOXY-BASED MONOLITHS | - |
dc.subject | IN-VITRO RELEASE | - |
dc.subject | POROUS SCAFFOLDS | - |
dc.subject | FABRICATION | - |
dc.subject | PARTICLES | - |
dc.subject | PROFILES | - |
dc.subject | SURFACE | - |
dc.subject | SIZE | - |
dc.subject | PARTICULATE | - |
dc.title | Production of CNT-taxol-embedded PCL microspheres using an ammonium-based room temperature ionic liquid: As a sustained drug delivery system | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Ji-Young | - |
dc.identifier.doi | 10.1016/j.jcis.2014.11.044 | - |
dc.identifier.scopusid | 2-s2.0-84920265032 | - |
dc.identifier.wosid | 000347671900019 | - |
dc.identifier.bibliographicCitation | JOURNAL OF COLLOID AND INTERFACE SCIENCE, v.442, pp.147 - 153 | - |
dc.relation.isPartOf | JOURNAL OF COLLOID AND INTERFACE SCIENCE | - |
dc.citation.title | JOURNAL OF COLLOID AND INTERFACE SCIENCE | - |
dc.citation.volume | 442 | - |
dc.citation.startPage | 147 | - |
dc.citation.endPage | 153 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.subject.keywordPlus | SELF-ASSEMBLED MONOLAYERS | - |
dc.subject.keywordPlus | EPOXY-BASED MONOLITHS | - |
dc.subject.keywordPlus | IN-VITRO RELEASE | - |
dc.subject.keywordPlus | POROUS SCAFFOLDS | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | PROFILES | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | PARTICULATE | - |
dc.subject.keywordAuthor | Taxol-loaded PCL microspheres | - |
dc.subject.keywordAuthor | Room temperature ionic liquids | - |
dc.subject.keywordAuthor | A sustained drug delivery system | - |
dc.subject.keywordAuthor | One-pot mass production | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.