Optimal hemoglobin level for anemia treatment in a cohort of hemodialysis patients
- Authors
- Jung, Mi Yeon; Hwang, Soon Young; Hong, Yu Ah; Oh, Su Young; Seo, Jae Hee; Lee, Young Mo; Park, Sang Won; Kim, Jung Sun; Wang, Joon Kwang; Kim, Jeong Yup; Lee, Ji Eun; Ko, Gang Jee; Pyo, Heui Jung; Kwon, Young Joo
- Issue Date
- 3월-2015
- Publisher
- KOREAN SOC NEPHROLOGY
- Keywords
- Anemia; Hemodialysis; Hemoglobin; Mortality
- Citation
- KIDNEY RESEARCH AND CLINICAL PRACTICE, v.34, no.1, pp.20 - 27
- Indexed
- SCOPUS
KCI
- Journal Title
- KIDNEY RESEARCH AND CLINICAL PRACTICE
- Volume
- 34
- Number
- 1
- Start Page
- 20
- End Page
- 27
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94279
- DOI
- 10.1016/j.krcp.2014.11.003
- ISSN
- 2211-9132
- Abstract
- Background: Anemia is a major risk factor that contributes to mortality in patients with chronic kidney disease. There is controversy over the optimal hemoglobin (1-lb) target in these patients. This study investigated the association between Hb level and mortality in a cohort of hemodialysis (HD) patients in Korea. Methods: This study was a multicenter prospective observational study of maintenance HD patients that was performed for 5 years in western Seoul, Korea. Three hundred and sixty-two participants were enrolled. Laboratory values and mortality were accessed every 6 months. Repeated measures of laboratory values in each interval were averaged to obtain one semiannual mean value. The Hb values were divided into six groups: (1) Hb < 9 g/dL; (2) 9 g/dL <= Hb < 10 g/dL; (3) 10 g/dL <= Hb < 11 g/dL; (4) 11 g/dL <= Hb < 12 g/dL; (5) 12 g/dL <= Hb < 13 g/dL; and (6) Hb >= 13 g/dL. We analyzed the odds ratio for all-cause mortality, based on the Hb group, and adjusted for demographics and various laboratory values. Statistics were performed with SAS, version 9.1 software (SAS Institute Inc., Cary, NC, USA), Results: Mortality odds ratios relative to the reference group (10-11 g/dL) in the fully adjusted model were 3.61 for <9 g/dL; 3.17 for 9-10 g/dL*; 4.65 for 11-12 g/dL*; 5.50 for 12-13 g/dL*; and 2.05 for >= 13 g/dL (* indicates P < 0.05). Conclusion: In this study, a lib level of 10-11 g/dL was associated with the lowest mortality among the groups with lib level < 13 g/dL. Larger interventional trials are warranted to determine the optimal lib target for Korean HD patients. Copyright (C) 2015. The Korean Society of Nephrology. Published by Elsevier.
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