The Influence of Alcoholic Liver Disease on Serum PIVKA-II Levels in Patients without Hepatocellular Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Kang, Keunhee | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Kang, Seong Hee | - |
dc.contributor.author | Lee, Beom Jae | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Park, Jong-Jae | - |
dc.contributor.author | Kim, Jae Seon | - |
dc.contributor.author | Bak, Young-Tae | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.date.accessioned | 2021-09-04T18:44:30Z | - |
dc.date.available | 2021-09-04T18:44:30Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94293 | - |
dc.description.abstract | Background/Aims: Prothrombin induced by vitamin K deficiency or antagonist II (PIVKA-II) is a widely used diagnostic marker for hepatocellular carcinoma (HCC). We evaluated the correlation between alcoholic liver disease (ALD) and serum PIVKA-II levels in chronic liver disease (CLD) patients. Methods: We retrospectively reviewed the medical records of 2,528 CLD patients without HCC. Among these patients, 76 exhibited serum high PIVKA-II levels of >125 mAU/mL (group 1). We categorized 76 control patients matched by age, sex, and the presence of liver cirrhosis from the remaining patients who were negative for serum PIVKA-II (group 2). Results: Group 1 revealed increased antibiotic usage (23.7% vs 2.6%, p<0.001) and incidence of ALD (60.5% vs 14.5%, p<0.001) as well as elevated aspartate aminotransferase (52.5 IU/L vs 30.5 IU/L, p=0.025) and 7 glutamyl transpeptidase (67.5 ILIA vs 36.5 IU/L, p=0.005) levels compared with group 2. Further, group 1 was significantly associated with a worse Child-Pugh class than group 2. In the multivariate analysiS, ALD (odds ratio [OR], 7.151; p<0.001) and antibiotic usage (OR, 5.846; p<0.001) were significantly associated with positive PIVKA-Il levels. Conclusions: Our study suggests that ALD and antibiotics usage may be confounding factors when interpreting high serum PIVKA-II levels in patients without HCC. Therefore, serum PIVKA-II levels in patients with ALD or in patients administered antibiotics should be interpreted with caution. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.subject | GAMMA-CARBOXY PROTHROMBIN | - |
dc.subject | VITAMIN-K METABOLISM | - |
dc.subject | ALPHA-FETOPROTEIN | - |
dc.subject | ABNORMAL PROTHROMBIN | - |
dc.subject | COAGULATION-FACTORS | - |
dc.subject | ENZYME-IMMUNOASSAY | - |
dc.subject | PLASMA | - |
dc.subject | MARKER | - |
dc.subject | CARBOXYPROTHROMBIN | - |
dc.subject | PROTEIN | - |
dc.title | The Influence of Alcoholic Liver Disease on Serum PIVKA-II Levels in Patients without Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Beom Jae | - |
dc.contributor.affiliatedAuthor | Seo, Yeon Seok | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Joon | - |
dc.contributor.affiliatedAuthor | Yeon, Jong Eun | - |
dc.contributor.affiliatedAuthor | Park, Jong-Jae | - |
dc.contributor.affiliatedAuthor | Kim, Jae Seon | - |
dc.contributor.affiliatedAuthor | Bak, Young-Tae | - |
dc.contributor.affiliatedAuthor | Byun, Kwan Soo | - |
dc.identifier.doi | 10.5009/gnl14047 | - |
dc.identifier.scopusid | 2-s2.0-84923641775 | - |
dc.identifier.wosid | 000350538700018 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.9, no.2, pp.224 - 230 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 224 | - |
dc.citation.endPage | 230 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001971170 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | GAMMA-CARBOXY PROTHROMBIN | - |
dc.subject.keywordPlus | VITAMIN-K METABOLISM | - |
dc.subject.keywordPlus | ALPHA-FETOPROTEIN | - |
dc.subject.keywordPlus | ABNORMAL PROTHROMBIN | - |
dc.subject.keywordPlus | COAGULATION-FACTORS | - |
dc.subject.keywordPlus | ENZYME-IMMUNOASSAY | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | CARBOXYPROTHROMBIN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Prothrombin induced by vitamin K deficiency or antagonist II | - |
dc.subject.keywordAuthor | Liver diseases | - |
dc.subject.keywordAuthor | alcoholic | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
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