The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Song, Gwan Gyu | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Kim, Jae-Hoon | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-04T18:55:35Z | - |
dc.date.available | 2021-09-04T18:55:35Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1470-3203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94333 | - |
dc.description.abstract | Introduction: The purpose of this study was to examine whether the insertion (I) and deletion (D) of angiotensin-converting enzyme (ACE) polymorphism confers susceptibility to psoriasis, vitiligo and rheumatoid arthritis (RA). Materials and methods: A meta-analysis was conducted on the association between the ACE I/D polymorphisms and psoriasis, vitiligo and RA. Results: Fifteen studies comprising five on psoriasis, five on vitiligo and five on RA were available for the meta-analysis consisting of 2094 cases and 2871 controls. Meta-analysis of the DD+ID genotype showed significant associations with psoriasis (odds ratio (OR) 0.753, 95% confidence interval (CI) 0.601-0.921, p = 0.006). Meta-analysis showed no association between vitiligo and the ACE I/D polymorphism. Meta-analysis of the DD+ID genotype showed an association with RA (OR 2.199, 95% CI 1.379-3.506, p = 0.001). Ethnicity-specific meta-analysis of the D allele showed no association with psoriasis in Europeans, and vitiligo in South Asians. However, subgroup analysis by ethnicity revealed a significant association between the D allele and RA in Arab populations (OR 2.697, 95% CI 1.803-4.034, p = 1.3 x 10(-5)). Conclusions: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to RA, especially in Arab populations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | GENE I/D POLYMORPHISM | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | GENERALIZED VITILIGO | - |
dc.subject | DELETION POLYMORPHISM | - |
dc.subject | ASSOCIATION | - |
dc.subject | ACE | - |
dc.subject | POPULATION | - |
dc.subject | SKIN | - |
dc.subject | DISEASE | - |
dc.subject | INFLAMMATION | - |
dc.title | The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1177/1470320313478285 | - |
dc.identifier.scopusid | 2-s2.0-84924964485 | - |
dc.identifier.wosid | 000350874800025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v.16, no.1, pp.195 - 202 | - |
dc.relation.isPartOf | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | - |
dc.citation.title | JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 195 | - |
dc.citation.endPage | 202 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | GENE I/D POLYMORPHISM | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | GENERALIZED VITILIGO | - |
dc.subject.keywordPlus | DELETION POLYMORPHISM | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ACE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | Angiotensin-converting enzyme | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | psoriasis | - |
dc.subject.keywordAuthor | vitiligo | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
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