Evaluation of a Cu-64-labeled 1,4,7-triazacyclononane, 1-glutaric acid-4,7 acetic acid (NODAGA)-galactose-bombesin analogue as a PET imaging probe in a gastrin-releasing peptide receptor-expressing prostate cancer xenograft model
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Hwan | - |
dc.contributor.author | Park, Ji Ae | - |
dc.contributor.author | Woo, Sang-Keun | - |
dc.contributor.author | Lee, Kyo Chul | - |
dc.contributor.author | An, Gwang Il | - |
dc.contributor.author | Kim, Byoung Soo | - |
dc.contributor.author | Kim, Kwang Il | - |
dc.contributor.author | Lee, Tae Sup | - |
dc.contributor.author | Kim, Chan Wha | - |
dc.contributor.author | Kim, Kyeong Min | - |
dc.contributor.author | Kang, Joo Hyun | - |
dc.contributor.author | Lee, Yong Jin | - |
dc.date.accessioned | 2021-09-04T18:57:15Z | - |
dc.date.available | 2021-09-04T18:57:15Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94346 | - |
dc.description.abstract | Gastrin-releasing peptide receptor (GRPR) is overexpressed by a variety of human tumors and in particular, identified to be upregulated in prostate cancers. The current study aimed to develop clinically translatable BBN analogue-based radioligands for positron emission tomography (PET) of GRPR-positive tumors. We developed radiolabeled BBN analogues and modified radiolabeled galacto-BBN analogues and then investigated their tumor-targeting efficacy in vivo. The chelator 1,4,7-triazacyclononane, 1-glutaric acid-4,7 acetic acid (NODAGA) was used to radiolabel the peptides with Cu-64. The peptides were evaluated by measuring cell-based receptor-binding affinities. Biodistribution experiments and small animal imaging using PET were performed in nude mice bearing subcutaneous PC3 human prostate cancer xenografts. The conjugates were radiolabeled with yields >99%. The stability assay showed that [Cu-64] NODAGA-BBN and [Cu-64]NODAGA-galacto-BBN remained stable in both human and mouse serum for 1 h at 37 degrees C. PET images of PC3 tumor-bearing nude mice were acquired at 1, 3, 24, 48 and 72 h after injection. [64Cu]NODAGA-galacto-BBN showed retention in tumors for 72 h, low liver uptake, and rapid renal clearance. PET imaging results were also confirmed by biodistrubution 1 and 3 h after injection. [Cu-64]NODAGA-BBN and [Cu-64]NODAGA-galacto-BBN are promising new PET probes for GRPR-positive prostate cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | IN-VIVO EVALUATION | - |
dc.subject | BOMBESIN ANALOG | - |
dc.subject | CELLS | - |
dc.subject | TUMOR | - |
dc.subject | INTEGRIN | - |
dc.subject | VITRO | - |
dc.subject | ANTAGONIST | - |
dc.title | Evaluation of a Cu-64-labeled 1,4,7-triazacyclononane, 1-glutaric acid-4,7 acetic acid (NODAGA)-galactose-bombesin analogue as a PET imaging probe in a gastrin-releasing peptide receptor-expressing prostate cancer xenograft model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan Wha | - |
dc.identifier.doi | 10.3892/ijo.2015.2832 | - |
dc.identifier.scopusid | 2-s2.0-84921926434 | - |
dc.identifier.wosid | 000349061800028 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ONCOLOGY, v.46, no.3, pp.1159 - 1168 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF ONCOLOGY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1159 | - |
dc.citation.endPage | 1168 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | IN-VIVO EVALUATION | - |
dc.subject.keywordPlus | BOMBESIN ANALOG | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | INTEGRIN | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | ANTAGONIST | - |
dc.subject.keywordAuthor | bombesin | - |
dc.subject.keywordAuthor | Cu-64 | - |
dc.subject.keywordAuthor | positron emission tomography | - |
dc.subject.keywordAuthor | prostate cancer | - |
dc.subject.keywordAuthor | radiopharmaceuticals | - |
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