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Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Nahyun | - |
| dc.contributor.author | Cho, Kyu-Won | - |
| dc.contributor.author | Hong, Seong Su | - |
| dc.contributor.author | Hwang, Bang Yeon | - |
| dc.contributor.author | Chun, Taehoon | - |
| dc.contributor.author | Lee, Dongho | - |
| dc.date.accessioned | 2021-09-04T19:26:32Z | - |
| dc.date.available | 2021-09-04T19:26:32Z | - |
| dc.date.created | 2021-06-15 | - |
| dc.date.issued | 2015-02-01 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94434 | - |
| dc.description.abstract | Four new glabretal-type triterpenoids, dictabretols A-D (1-4), were isolated by activity-guided fractionation from the root bark of Dictamnus dasycarpus T. (Rutaceae) using an in vitro antiproliferative assay on T cells using splenocytes. The structures of these compounds were determined by spectroscopic methods, including 2D NMR experiments. Compounds were evaluated for their immunosuppressive activity on T cells and demonstrated inhibition of proliferation of activated T cells, up to IC50 of 1.5 mu M. (C) 2014 Elsevier Ltd. All rights reserved. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.subject | TIRUCALLANE TRITERPENOIDS | - |
| dc.subject | CONSTITUENTS | - |
| dc.subject | ALKALOIDS | - |
| dc.subject | ALBUS | - |
| dc.subject | APOTIRUCALLANE | - |
| dc.subject | CYCLOSPORINE | - |
| dc.subject | GLYCOSIDES | - |
| dc.subject | CELLS | - |
| dc.subject | ACIDS | - |
| dc.title | Antiproliferative glabretal-type triterpenoids from the root bark of Dictamnus dasycarpus | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Chun, Taehoon | - |
| dc.contributor.affiliatedAuthor | Lee, Dongho | - |
| dc.identifier.doi | 10.1016/j.bmcl.2014.12.007 | - |
| dc.identifier.scopusid | 2-s2.0-84920727361 | - |
| dc.identifier.wosid | 000347901700037 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.25, no.3, pp.621 - 625 | - |
| dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 25 | - |
| dc.citation.number | 3 | - |
| dc.citation.startPage | 621 | - |
| dc.citation.endPage | 625 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | TIRUCALLANE TRITERPENOIDS | - |
| dc.subject.keywordPlus | CONSTITUENTS | - |
| dc.subject.keywordPlus | ALKALOIDS | - |
| dc.subject.keywordPlus | ALBUS | - |
| dc.subject.keywordPlus | APOTIRUCALLANE | - |
| dc.subject.keywordPlus | CYCLOSPORINE | - |
| dc.subject.keywordPlus | GLYCOSIDES | - |
| dc.subject.keywordPlus | CELLS | - |
| dc.subject.keywordPlus | ACIDS | - |
| dc.subject.keywordAuthor | Dictamnus dasycarpus | - |
| dc.subject.keywordAuthor | Rutaceae | - |
| dc.subject.keywordAuthor | Glabretal-type triterpenoid | - |
| dc.subject.keywordAuthor | Antiproliferative effect | - |
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology