Association of brain-derived neurotrophic factor DNA methylation and reduced white matter integrity in the anterior corona radiata in major depression
- Authors
- Choi, Sunyoung; Han, Kyu-Man; Won, Eunsoo; Yoon, Bong-June; Lee, Min-Soo; Ham, Byung-Joo
- Issue Date
- 1-2월-2015
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Brain-derived neurotropluc factor (BDNF); DNA methylation; Major depressive disorder; Anterior corona radiata; Diffusion tensor imaging (DTI)
- Citation
- JOURNAL OF AFFECTIVE DISORDERS, v.172, pp.74 - 80
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- JOURNAL OF AFFECTIVE DISORDERS
- Volume
- 172
- Start Page
- 74
- End Page
- 80
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94438
- DOI
- 10.1016/j.jad.2014.09.042
- ISSN
- 0165-0327
- Abstract
- Considerable evidence suggests a crucial role for the epigenetic regulation of brain derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD). However, the relationship between BONE DNA methylation and white matter (WM) integrity in MDD has not yet been investigated. In the current study, we examined the association between the DNA methylation status of the BONE promoter region and WM integrity in MDD. Sixty patients with MDD and 53 healthy controls underwent T1-weighted structural magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI), to assess their WM integrity. BDNE DNA methylation at 4 CpG sites of the promoter region was also measured. As compared to healthy controls, the MDD group demonstrated reduced fractional anisotropy (FA) in the bilateral anterior and posterior corona radiata (ACR and PCR), genu of the corpus callosum, and the bilateral posterior thalamic radiations. We observed a significant inverse correlation between the DNA methylation of the BDNF promoter region and the FA of the right ACR in MDD patients. Our findings demonstrate a relationship between meLhylaLion of the BDNF promoter region and the integrity of the ACR, a key structural component of the emotional and cognitive control network involved in the pathophysiology of MDD. This correlation suggests that BDNF DNA methylation may contribute to structural WM changes in MDD patients. (C) 2014 Elsevier B.V. All rights reserved.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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