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Discovery of a Novel Series of Indolyl Hydrazide Derivatives as Diacylglycerol Acyltransferase-1 Inhibitors
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Minkyoung | - |
| dc.contributor.author | Kwon, Jinsun | - |
| dc.contributor.author | Kim, Mun Ock | - |
| dc.contributor.author | Singh, Sarbjit | - |
| dc.contributor.author | Kim, Sang Kyum | - |
| dc.contributor.author | Lee, Kyeong | - |
| dc.contributor.author | Lee, Kiho | - |
| dc.contributor.author | Lee, Hyun Sun | - |
| dc.contributor.author | Choi, Yongseok | - |
| dc.date.accessioned | 2021-09-04T19:28:46Z | - |
| dc.date.available | 2021-09-04T19:28:46Z | - |
| dc.date.created | 2021-06-15 | - |
| dc.date.issued | 2015-02 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94450 | - |
| dc.description.abstract | A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | WILEY-V C H VERLAG GMBH | - |
| dc.subject | OPTIMIZATION | - |
| dc.subject | POTENT | - |
| dc.title | Discovery of a Novel Series of Indolyl Hydrazide Derivatives as Diacylglycerol Acyltransferase-1 Inhibitors | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Lee, Kiho | - |
| dc.contributor.affiliatedAuthor | Choi, Yongseok | - |
| dc.identifier.doi | 10.1002/bkcs.10123 | - |
| dc.identifier.scopusid | 2-s2.0-84928324261 | - |
| dc.identifier.wosid | 000353571500034 | - |
| dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.36, no.2, pp.628 - 635 | - |
| dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.citation.volume | 36 | - |
| dc.citation.number | 2 | - |
| dc.citation.startPage | 628 | - |
| dc.citation.endPage | 635 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.identifier.kciid | ART001960628 | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | OPTIMIZATION | - |
| dc.subject.keywordPlus | POTENT | - |
| dc.subject.keywordAuthor | Diacylglycerol O-acyltransferase inhibitor | - |
| dc.subject.keywordAuthor | Triglyceride | - |
| dc.subject.keywordAuthor | Obesity | - |
| dc.subject.keywordAuthor | Hydrazide | - |
| dc.subject.keywordAuthor | Diacylglycerol O-acyltransferase | - |
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