Prospective Cohort Study on the Effectiveness of Influenza and Pneumococcal Vaccines in Preventing Pneumonia Development and Hospitalization
- Authors
- Song, Joon Young; Lee, Jin Soo; Wie, Seong-Heon; Kim, Hyo Youl; Lee, Jacob; Bin Seo, Yu; Jeong, Hye Won; Kim, Shin Woo; Lee, Sun Hee; Park, Kyung-Hwa; Noh, Ji Yun; Choi, Won Suk; Cheong, Hee Jin; Kim, Woo Joo
- Issue Date
- 2월-2015
- Publisher
- AMER SOC MICROBIOLOGY
- Citation
- CLINICAL AND VACCINE IMMUNOLOGY, v.22, no.2, pp.229 - 234
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL AND VACCINE IMMUNOLOGY
- Volume
- 22
- Number
- 2
- Start Page
- 229
- End Page
- 234
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/94511
- DOI
- 10.1128/CVI.00673-14
- ISSN
- 1556-6811
- Abstract
- Pneumonia and acute exacerbation of chronic illness are leading causes of influenza-related hospitalization. Therefore, influenza and pneumococcal vaccinations are strongly recommended for adults with comorbidities. Using a hospital-based influenza surveillance system, we performed a multicenter, prospective cohort study of patients visiting emergency rooms with influenza-like illness (ILI) during the influenza epidemic period in 2013 to 2014. Patients aged >= 19 years were enrolled, and clinical data were collected. Multivariate analyses were performed to estimate the effectiveness of influenza and pneumococcal vaccination in preventing pneumonia development and hospitalization. During study periods, 2,262 patients with ILI were registered. Among 2,217 patients with available vaccination records, 31.9% (707 patients) and 9.7% (216 patients) had received influenza and pneumococcal vaccines, respectively. Among patients who had been administered a pneumococcal vaccine, 94.4% had received the 23-valent polysaccharide vaccine (PPV23). The adjusted rates of effectiveness of the influenza vaccine for preventing pneumonia development and hospitalization were 64.0% (95% confidence interval [CI] = 29% to 81%) and 35.0% (95% CI = 12% to 52%), respectively. Pneumococcal vaccination did not reduce pneumonia development or hospitalization. In conclusion, influenza rather than PPV23 vaccination may reduce pneumonia development and hospitalization in patients with preceding ILI.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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