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Transcranial direct current stimulation on primary sensorimotor area has no effect in patients with drug- naive restless legs syndrome: a proof-of-concept clinical trial

Authors
Koo, Yong SeoKim, Sung MinLee, ChanyLee, Byeong UkMoon, Ye JiCho, Yong WonIm, Chang-HwanChoi, Jeong WooKim, Kyung HwanJung, Ki-Young
Issue Date
2월-2015
Publisher
ELSEVIER
Keywords
Restless legs syndrome; Transcranial direct current stimulation; Cortical excitability; Non-pharmacological treatment; Event-related synchronization
Citation
SLEEP MEDICINE, v.16, no.2, pp.280 - 287
Indexed
SCIE
SCOPUS
Journal Title
SLEEP MEDICINE
Volume
16
Number
2
Start Page
280
End Page
287
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/94585
DOI
10.1016/j.sleep.2014.07.032
ISSN
1389-9457
Abstract
Objective: To evaluate the efficacy of transcranial direct current stimulation (tDCS) in people with drugnaive restless legs syndrome (RLS). Methods: A two-week, double-blind, randomized, sham-controlled trialwas performed. Thirty-three females with RLS were recruited. Participants received five sessions of tDCS using cathodal, anodal or sham stimulation. They were assessed at baseline (T0), three days (T1) and 13 days (T2) after the end of tDCS. Primary outcomes included the International RLS Group Rating Scale (IRLS) and the Clinical Global ImpressionsImprovement (CGI-I). Secondary outcomes included the Patient Global Impression scale, the Pittsburgh Sleep Quality Index, the Medical Outcome Study sleep subscales, and the Beck Depression Inventory. Objective neurophysiological changes were assessed using event-related desynchronization/synchronization (ERD/ERS) of electroencephalography. Results: The changes in the IRLS scores, as well as the responder rate in the CGI-I scale, did not differ significantly among the groups. There was also no significant difference in any of the secondary outcome measures and ERD/ERS among the groups. Conclusions: Transcranial direct current stimulation with electrodes on the sensorimotor areas showed no significant effect in people with drug-naive RLS. (C) 2014 Elsevier B.V. All rights reserved.
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