Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression
DC Field | Value | Language |
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dc.contributor.author | Lee, Sehe Dong | - |
dc.contributor.author | Choe, Jung Wan | - |
dc.contributor.author | Lee, Beom Jae | - |
dc.contributor.author | Kang, Myoung Hee | - |
dc.contributor.author | Joo, Moon Kyung | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Park, Jong-Jae | - |
dc.contributor.author | Kim, Jae Seon | - |
dc.contributor.author | Bak, Young-Tae | - |
dc.date.accessioned | 2021-09-04T20:03:33Z | - |
dc.date.available | 2021-09-04T20:03:33Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-01-14 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94645 | - |
dc.description.abstract | AIM: To evaluate the effects of butein on inflammatory cytokines, matrix metalloproteinase-9 (MMP-9), and colitis in interleukin (IL)-10(-/-) mice. METHODS: To synchronize colitis, 8- to 10-wk-old IL-10(-/-) mice were fed pellet-chow containing piroxicam for 2 wk. Subsequently, phosphate-buffered saline or butein (1 mg/kg per day, ip) was injected for 4 wk. Histologic scores, inflammatory cytokines, MMP-9 and phosphorylated signal transducer and activator of transcription 3 (pSTAT3) expressions were analyzed in IL-10(-/-) mice and in Colo 205 cells. RESULTS: Butein reduced the colonic inflammatory score by > 50%. Expression levels of IL-6, IL-1 beta, interferon (IFN)-gamma and MMP-9 were decreased in the colons of mice exposed to butein, whereas other inflammatory cytokines (IL-17A, IL-21 and IL-22) were unchanged. Immunohistochemical staining for pSTAT3 and MMP-9 was significantly decreased in the butein-treated groups compared with the controls. Butein inhibited IL-6-induced activation of STAT3 in Colo 205 cells. CONCLUSION: Butein ameliorated colitis in IL-10(-/-) mice by regulating IL-6/STAT3 and MMP-9 activation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.subject | INFLAMMATORY BOWEL DISEASES | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | CANCER CHEMOPREVENTION | - |
dc.subject | DIETARY PHYTOCHEMICALS | - |
dc.subject | IL-10-DEFICIENT MICE | - |
dc.subject | ULCERATIVE-COLITIS | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | APOPTOSIS | - |
dc.subject | PATHWAYS | - |
dc.title | Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Beom Jae | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hoon | - |
dc.contributor.affiliatedAuthor | Yeon, Jong Eun | - |
dc.contributor.affiliatedAuthor | Park, Jong-Jae | - |
dc.contributor.affiliatedAuthor | Kim, Jae Seon | - |
dc.contributor.affiliatedAuthor | Bak, Young-Tae | - |
dc.identifier.doi | 10.3748/wjg.v21.i2.465 | - |
dc.identifier.scopusid | 2-s2.0-84920972606 | - |
dc.identifier.wosid | 000348419200009 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.21, no.2, pp.465 - 474 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 21 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 465 | - |
dc.citation.endPage | 474 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | INFLAMMATORY BOWEL DISEASES | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | CANCER CHEMOPREVENTION | - |
dc.subject.keywordPlus | DIETARY PHYTOCHEMICALS | - |
dc.subject.keywordPlus | IL-10-DEFICIENT MICE | - |
dc.subject.keywordPlus | ULCERATIVE-COLITIS | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordAuthor | Butein | - |
dc.subject.keywordAuthor | Interleukin-6/signal transducer and activator of transcription 3 | - |
dc.subject.keywordAuthor | Colitis | - |
dc.subject.keywordAuthor | Inflammatory bowel disease | - |
dc.subject.keywordAuthor | Matrix metalloproteinase-9 | - |
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