ScholarWorks@Korea University

Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Overexpression of malic enzyme in the larval stage extends Drosophila lifespan

Full metadata record
DC Field Value Language
dc.contributor.authorKim, Gye-Hyeong-
dc.contributor.authorLee, Young-Eun-
dc.contributor.authorLee, Gun-Ho-
dc.contributor.authorCho, Youn-Ho-
dc.contributor.authorLee, Young-Nam-
dc.contributor.authorJang, Yeogil-
dc.contributor.authorPaik, Donggi-
dc.contributor.authorPark, Joong-Jean-
dc.date.accessioned2021-09-04T20:10:15Z-
dc.date.available2021-09-04T20:10:15Z-
dc.date.created2021-06-15-
dc.date.issued2015-01-09-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/94652-
dc.description.abstractMetabolic modifications during the developmental period can extend longevity. We found that malic enzyme (Men) overexpression during the larval period lengthened the lifespan of Drosophila. Men overexpression by S106-GeneSwitch-Gal4 driver increased pyruvate content and NADPH/NADP(+) ratio but reduced triglyceride, glycogen, and ATP levels in the larvae. ROS levels increased unexpectedly in Men-overexpressing larvae. Interestingly, adults exposed to larval Men-overexpression maintained ROS tolerance with enhanced expression levels of glutathione-S-transferase D2 and thioredoxin-2. Our results suggest that metabolic changes mediated by Men during development might be related to the control of ROS tolerance and the longevity of Drosophila. (C) 2014 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectCYTOSOLIC MALATE-DEHYDROGENASE-
dc.subjectATP-CITRATE LYASE-
dc.subjectCALORIC RESTRICTION-
dc.subjectOXIDATIVE STRESS-
dc.subjectJUVENILE-HORMONE-
dc.subjectTHYROID-HORMONE-
dc.subjectCAENORHABDITIS-ELEGANS-
dc.subjectDIETARY RESTRICTION-
dc.subjectINSULIN-SECRETION-
dc.subjectRHESUS-MONKEYS-
dc.titleOverexpression of malic enzyme in the larval stage extends Drosophila lifespan-
dc.typeArticle-
dc.contributor.affiliatedAuthorPark, Joong-Jean-
dc.identifier.doi10.1016/j.bbrc.2014.12.020-
dc.identifier.scopusid2-s2.0-84919911772-
dc.identifier.wosid000348695700023-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.456, no.2, pp.676 - 682-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume456-
dc.citation.number2-
dc.citation.startPage676-
dc.citation.endPage682-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.subject.keywordPlusCYTOSOLIC MALATE-DEHYDROGENASE-
dc.subject.keywordPlusATP-CITRATE LYASE-
dc.subject.keywordPlusCALORIC RESTRICTION-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusJUVENILE-HORMONE-
dc.subject.keywordPlusTHYROID-HORMONE-
dc.subject.keywordPlusCAENORHABDITIS-ELEGANS-
dc.subject.keywordPlusDIETARY RESTRICTION-
dc.subject.keywordPlusINSULIN-SECRETION-
dc.subject.keywordPlusRHESUS-MONKEYS-
dc.subject.keywordAuthorMalic enzyme-
dc.subject.keywordAuthorPyruvate-
dc.subject.keywordAuthorLongevity-
dc.subject.keywordAuthorROS-
dc.subject.keywordAuthorDrosophila-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles
Show simple item record

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

STATISTICS
Total View :8,743,516
Today View :26,435

RSS_1.0 RSS_2.0 ATOM_1.0

CONTACT US

(02841) 서울특별시 성북구 안암로 14502-3290-1114

COPYRIGHT © 2021 Korea University. All Rights Reserved.

Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.

BROWSE

English