Lipid-Soluble Ginseng Extract Inhibits Invasion and Metastasis of B16F10 Melanoma Cells
DC Field | Value | Language |
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dc.contributor.author | Yun, Jieun | - |
dc.contributor.author | Kim, Bo Geun | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.contributor.author | Park, Song-Kyu | - |
dc.contributor.author | Lee, Kiho | - |
dc.contributor.author | Hyun, Dong-Hoon | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.contributor.author | In, Man-Jin | - |
dc.contributor.author | Kim, Dong Chung | - |
dc.date.accessioned | 2021-09-04T20:15:31Z | - |
dc.date.available | 2021-09-04T20:15:31Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-01-01 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94684 | - |
dc.description.abstract | This study was performed to elucidate the effect of a lipid-soluble ginseng extract (LSGE) on cancer invasion and metastasis. The LSGE, even at noncytotoxic concentrations, potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner. In the presence of 3 mu g/mL of LSGE, the invasion and migration of B16F10 cells were significantly inhibited by 98.1% and 71.4%, respectively. Furthermore, the LSGE decreased mRNA and protein levels of matrix metalloproteinase (MMP)-2 in B16F10 cells, leading to a decrease in MMP-2 activity. After B16F10 cells were intravenously injected in the tail vein of C57BL/6 mice, 1000 mg/kg/day of LSGE was orally administered for 13 days, after which lung metastasis of cancer cells was inhibited by 59.3%. These findings indicate that LSGE inhibits cancer cell invasion and migration in vitro and lung metastasis of melanoma cells in vivo by inhibiting MMP-2 expression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.subject | LUNG-CANCER | - |
dc.subject | PANAX-GINSENG | - |
dc.subject | TUMOR-GROWTH | - |
dc.subject | CYCLE ARREST | - |
dc.subject | IN-VITRO | - |
dc.subject | SAPONINS | - |
dc.subject | PROLIFERATION | - |
dc.subject | GELATINASES | - |
dc.subject | APOPTOSIS | - |
dc.subject | RH-2 | - |
dc.title | Lipid-Soluble Ginseng Extract Inhibits Invasion and Metastasis of B16F10 Melanoma Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Song-Kyu | - |
dc.contributor.affiliatedAuthor | Lee, Kiho | - |
dc.identifier.doi | 10.1089/jmf.2013.3138 | - |
dc.identifier.scopusid | 2-s2.0-84920735081 | - |
dc.identifier.wosid | 000347393400012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.18, no.1, pp.102 - 108 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 102 | - |
dc.citation.endPage | 108 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001957754 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | LUNG-CANCER | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | CYCLE ARREST | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SAPONINS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | GELATINASES | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | RH-2 | - |
dc.subject.keywordAuthor | lung metastasis | - |
dc.subject.keywordAuthor | cancer invasion | - |
dc.subject.keywordAuthor | matrix metalloprotease-2 | - |
dc.subject.keywordAuthor | lipid-soluble ginseng extract | - |
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