Expression of astrocyte elevated gene-1 (AEG-1) in human meningiomas and its roles in cell proliferation and survival
DC Field | Value | Language |
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dc.contributor.author | Park, Kyung-Jae | - |
dc.contributor.author | Yu, Mi Ok | - |
dc.contributor.author | Song, Na-Hyun | - |
dc.contributor.author | Kong, Doo-Sik | - |
dc.contributor.author | Park, Dong-Hyuk | - |
dc.contributor.author | Chae, Yang-Seok | - |
dc.contributor.author | Chung, Yong-Gu | - |
dc.contributor.author | Kang, Shin-Hyuk | - |
dc.date.accessioned | 2021-09-04T20:31:02Z | - |
dc.date.available | 2021-09-04T20:31:02Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 0167-594X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94792 | - |
dc.description.abstract | Astrocyte elevated gene-1 (AEG-1) has recently been proposed to be involved in tumor development, invasion, and metastasis in several human cancers. However, the functional importance of AEG-1 expression in human meningioma has not been determined. We investigate the level of AEG-1 expression by quantitative reverse transcription PCR, immunohistochemistry analysis, and western blotting in various human meningioma tissues and cells. To determine the suppressive effect of AEG-1 on meningioma progression, we inhibited AEG-1 expression using small interfering RNA and examined cell proliferation, apoptosis, colony formation and tumorigenicity in a mouse xenograft model. AEG-1 expression was frequently elevated at both mRNA and protein levels in meningioma tumor tissues and in meningioma-derived cells as well. This elevation was more commonly observed in high-grade tumors than in benign ones. The knockdown of AEG-1 led to a decrease in overall cell proliferation, as well as anchorage-independent growth of malignant meningioma. In addition, apoptotic cell death occurred in AEG-1 depleted meningioma cells through p-Akt and Bcl-2 suppression. Furthermore, a mouse xenograft meningioma model showed that inhibition of AEG-1 expression significantly decreased tumor growth. Altogether, these data show that the elevation of AEG-1 contributes to the malignant progression of meningiomas, suggesting that AEG-1 could be a novel therapeutic target against human meningiomas. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | RAPID SUBTRACTION HYBRIDIZATION | - |
dc.subject | ANAPLASTIC MENINGIOMAS | - |
dc.subject | RECURRENT MENINGIOMAS | - |
dc.subject | CANCER | - |
dc.subject | PROGRESSION | - |
dc.subject | ACTIVATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | PATHWAY | - |
dc.subject | PROTEIN | - |
dc.subject | GROWTH | - |
dc.title | Expression of astrocyte elevated gene-1 (AEG-1) in human meningiomas and its roles in cell proliferation and survival | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyung-Jae | - |
dc.contributor.affiliatedAuthor | Park, Dong-Hyuk | - |
dc.contributor.affiliatedAuthor | Chae, Yang-Seok | - |
dc.contributor.affiliatedAuthor | Chung, Yong-Gu | - |
dc.contributor.affiliatedAuthor | Kang, Shin-Hyuk | - |
dc.identifier.doi | 10.1007/s11060-014-1603-2 | - |
dc.identifier.scopusid | 2-s2.0-84921031883 | - |
dc.identifier.wosid | 000347895100003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURO-ONCOLOGY, v.121, no.1, pp.31 - 39 | - |
dc.relation.isPartOf | JOURNAL OF NEURO-ONCOLOGY | - |
dc.citation.title | JOURNAL OF NEURO-ONCOLOGY | - |
dc.citation.volume | 121 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 39 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | RAPID SUBTRACTION HYBRIDIZATION | - |
dc.subject.keywordPlus | ANAPLASTIC MENINGIOMAS | - |
dc.subject.keywordPlus | RECURRENT MENINGIOMAS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Meningioma | - |
dc.subject.keywordAuthor | Astrocyte elevated gene-1 | - |
dc.subject.keywordAuthor | Progression | - |
dc.subject.keywordAuthor | Apoptosis | - |
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