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Quetiapine augmentation for depression: dosing pattern in routine practice

Authors
Pae, Chi-UnWang, Sheng-MinHan, ChangsuLee, Soo-JungPatkar, Ashwin A.Masand, Prakash S.
Issue Date
1월-2015
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
atypical antipsychotics; augmentation; doses; major depressive disorder; quetiapine
Citation
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, v.30, no.1, pp.54 - 58
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
Volume
30
Number
1
Start Page
54
End Page
58
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/94794
DOI
10.1097/YIC.0000000000000055
ISSN
0268-1315
Abstract
This study investigated the dosing patterns of quetiapine augmentation (QA) for major depressive disorder (MDD) in routine practice. Between 1 January 2009 and 31 May 2013, patients with a diagnosis of MDD who were receiving QA in conjunction with an ongoing antidepressant were recruited into this study. The electronic medical records and clinical data for a total of 977 patients were reviewed up to a year. Almost half the patients maintained QA treatment for more than 3 months. The mean duration of QA was similar to 6 months, and the mean initial and maintenance doses were 23.6 and 40.7 mg/day, respectively (range=12.5-400 mg/day). The most frequent adverse events observed were somnolence, followed by dry mouth and lethargy. Our results indicate that the actual doses of QA for MDD in routine practice should be lower than the doses used in placebo-controlled clinical trials and those recommended by a regulatory agency. Adequately powered and well-controlled prospective studies are needed to better understand the exact role of low doses of QA in the treatment of MDD, particularly in routine practice. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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