Effects of the interleukin-1 beta-511 C/T gene polymorphism on the risk of gastric cancer in the context of the relationship between race and H. pylori infection: a meta-analysis of 20,000 subjects
DC Field | Value | Language |
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dc.contributor.author | Park, Min-Jeong | - |
dc.contributor.author | Hyun, Myung-Han | - |
dc.contributor.author | Yang, Jong-Pill | - |
dc.contributor.author | Yoon, Jeong-Min | - |
dc.contributor.author | Park, Sungsoo | - |
dc.date.accessioned | 2021-09-04T20:31:28Z | - |
dc.date.available | 2021-09-04T20:31:28Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94795 | - |
dc.description.abstract | The interleukin (IL)-1 beta-511 C/T polymorphism has been shown to be functional and to contribute to the risk of gastric cancer. However, the relationship between the IL-1 beta-511 C/T polymorphism and gastric carcinogenesis remains inconclusive. A systematical electronic search was conducted of the MEDLINE, EMBASE, and CENTRAL databases. A random and a fixed effects model were exploited to estimate summary odds ratios and 95 % confidence intervals. Subgroup and sensitivity analyses were carried out with respect to ethnicity, quality assessment scores, control sources, genotyping methods, cancer histopathology and location, and Helicobacter pylori (H. pylori) infection. A total of 45 studies containing 9,066 cases of gastric cancer and 11,192 control subjects satisfied the inclusion criteria. The IL-1 beta-511 C/T polymorphism was found to enhance the risk of stomach cancer for overall and HWE-satisfying studies. Asians showed a positive relationship in both the overall and HWE-satisfying groups, whereas Caucasians did not. Based on subgroup analysis, H. pylori infection and genotype analysis using PCR-RFLP methods increase the association between IL-1 beta-511 T allele carrier and risk of stomach cancer. A positive relationship was found between the IL-1 beta-511 C/T SNP and stomach carcinoma susceptibility, and the results suggest that Asian ethnicity, H. pylori infection and methodologically, PCR-RFLP genotyping strengthen this relationship. Reflecting on prevalence of H. pylori in Asian countries, additional studies on the IL-1 beta-511 C/T SNP in the context of ethnicity and H. pylori infection may provide key insights into the mechanism underlying gastric cancer carcinogenesis. It was found PCR-RFLP is the most reliable genotyping method, and thus, it is recommendable to adopt it to determine the presence of the IL-1 beta-511 C/T SNP. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | RECEPTOR ANTAGONIST GENE | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | HARDY-WEINBERG EQUILIBRIUM | - |
dc.subject | EPSTEIN-BARR-VIRUS | - |
dc.subject | HELICOBACTER-PYLORI | - |
dc.subject | CHINESE POPULATION | - |
dc.subject | PROMOTER POLYMORPHISM | - |
dc.subject | ATROPHIC GASTRITIS | - |
dc.subject | ASSOCIATION | - |
dc.subject | CARCINOMA | - |
dc.title | Effects of the interleukin-1 beta-511 C/T gene polymorphism on the risk of gastric cancer in the context of the relationship between race and H. pylori infection: a meta-analysis of 20,000 subjects | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Sungsoo | - |
dc.identifier.doi | 10.1007/s11033-014-3748-7 | - |
dc.identifier.scopusid | 2-s2.0-84927122720 | - |
dc.identifier.wosid | 000349006400014 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.42, no.1, pp.119 - 134 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 119 | - |
dc.citation.endPage | 134 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | RECEPTOR ANTAGONIST GENE | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | HARDY-WEINBERG EQUILIBRIUM | - |
dc.subject.keywordPlus | EPSTEIN-BARR-VIRUS | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI | - |
dc.subject.keywordPlus | CHINESE POPULATION | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | ATROPHIC GASTRITIS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordAuthor | Interleukin-1beta | - |
dc.subject.keywordAuthor | IL-1 beta-511 | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordAuthor | Stomach neoplasm | - |
dc.subject.keywordAuthor | Single-nucleotide polymorphism | - |
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