Hippocampal volume and shape in pure subcortical vascular dementia
DC Field | Value | Language |
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dc.contributor.author | Kim, Geon Ha | - |
dc.contributor.author | Lee, Jae Hong | - |
dc.contributor.author | Seo, Sang Won | - |
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Seong, Joon-Kyung | - |
dc.contributor.author | Ye, Byoung Seok | - |
dc.contributor.author | Cho, Hanna | - |
dc.contributor.author | Noh, Young | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Yoon, Cindy W. | - |
dc.contributor.author | Oh, Seung Jun | - |
dc.contributor.author | Kim, Jae Seung | - |
dc.contributor.author | Choe, Yearn Seong | - |
dc.contributor.author | Lee, Kyung Han | - |
dc.contributor.author | Kim, Sung Tae | - |
dc.contributor.author | Hwang, Jung Won | - |
dc.contributor.author | Jeong, Jee Hyang | - |
dc.contributor.author | Na, Duk L. | - |
dc.date.accessioned | 2021-09-04T20:39:28Z | - |
dc.date.available | 2021-09-04T20:39:28Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/94847 | - |
dc.description.abstract | The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative C-11-Pittsburg compound-B (PiB(-)) positron emission tomography and to compare hippocampal volume and shape between PiB-SVaD and PiB positive (PiB(-)) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB(-)SVaD, 34 with PiB(+) AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB-SVaD was significantly smaller than NC but larger than that of PiB(+) AD (NC > PiB-SVaD > PiB(+) AD). Both PiB(-)SVaD and PiB(+) AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB(-)SVaD and PiB(+) AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB(-) AD. PiB(+) SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | COGNITIVE IMPAIRMENT | - |
dc.subject | PREDICT DEMENTIA | - |
dc.subject | ATROPHY | - |
dc.subject | MRI | - |
dc.subject | NEUROPATHOLOGY | - |
dc.subject | FEATURES | - |
dc.subject | AD | - |
dc.title | Hippocampal volume and shape in pure subcortical vascular dementia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seong, Joon-Kyung | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2014.08.009 | - |
dc.identifier.scopusid | 2-s2.0-84920382033 | - |
dc.identifier.wosid | 000347408600051 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF AGING, v.36, no.1, pp.485 - 491 | - |
dc.relation.isPartOf | NEUROBIOLOGY OF AGING | - |
dc.citation.title | NEUROBIOLOGY OF AGING | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 485 | - |
dc.citation.endPage | 491 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | PREDICT DEMENTIA | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | NEUROPATHOLOGY | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | AD | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Vascular dementia | - |
dc.subject.keywordAuthor | Hippocampus | - |
dc.subject.keywordAuthor | PiB-PET | - |
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