Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Risk Score Model for the Assessment of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes

Authors
Park, Gyung-MinAn, HyongginLee, Seung-WhanCho, Young-RakGil, Eun HaHer, Sung HoKim, Young-HakLee, Cheol WhanKoh, Eun HeeLee, Woo JeKim, Min-SeonLee, Ki-UpKang, Joon-WonLim, Tae-HwanPark, Seong-WookPark, Seung-JungPark, Joong-Yeol
Issue Date
1월-2015
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
MEDICINE, v.94, no.4
Indexed
SCIE
SCOPUS
Journal Title
MEDICINE
Volume
94
Number
4
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/94859
DOI
10.1097/MD.0000000000000508
ISSN
0025-7974
Abstract
No model has been developed to predict significant coronary artery disease (CAD) on coronary computed tomographic angiography (CCTA) in asymptomatic type 2 diabetes. Therefore, we sought to develop a model for the prediction of significant CAD on CCTA in these patients. We analyzed 607 asymptomatic patients with type 2 diabetes who underwent CCTA. The cardiac event was defined as a composite of cardiac death, nonfatal myocardial infarction, acute coronary syndrome, and coronary revascularization. Significant CAD (diameter stenosis >= 50%) in at least one coronary artery on CCTA was observed in 188 (31.0%). During the follow-up period (median 4.3 [interquartile range, 3.7-4.8] years), 71 patients had 83 cardiac events. Clinical risk factors for significant CAD were age, male gender, duration of diabetes, hypertension, current smoking, family history of premature CAD, previous history of stroke, ratio of total cholesterol to high-density lipoprotein cholesterol, and neuropathy. Using these variables, we formulated a risk score model, and the scores ranged from 0 to 17 (area under the curve = 0.727, 95% confidence interval = 0.714-0.739, P < 0.001). Patients were categorized into low (<= 3), intermediate (4-6), or high (>= 7) risk group. There were significant differences between the risk groups in the probability of significant CAD (12.6% vs 29.4% vs 57.7%, P for all < 0.001) and 5-year cardiac event-free survival rate (96.6% +/- 1.5% vs 88.9% +/- 1.8% vs 73.8% +/- 4.1%, log-rank P for trend < 0.001). This model predicts significant CAD on CCTA and has the potential to identify asymptomatic type 2 diabetes with high risk.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medical Science > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE