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Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer’s DiseaseFactors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer’s Disease

Other Titles
Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer’s Disease
Authors
나해리박문호김상윤양동원최성혜양현덕양영순한현정이정석윤영철고성호김정은구본대김희진박경원김은주윤보라박기정
Issue Date
2015
Publisher
대한치매학회
Keywords
rivastigmine transdermal patch; Alzheimer’s disease; tolerability.
Citation
Dementia and Neurocognitive Disorders(대한치매학회지), v.14, no.1, pp.31 - 38
Indexed
KCI
Journal Title
Dementia and Neurocognitive Disorders(대한치매학회지)
Volume
14
Number
1
Start Page
31
End Page
38
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/94965
DOI
10.12779/dnd.2015.14.1.31
ISSN
1738-1495
Abstract
Background and Purpose The one-day rivastigmine patch is reportedly well tolerated and has minimal side effects. However, Asian patientsshow more side effects than those in Western countries. We evaluated tolerability of the rivastigmine patch in South Korean patientswith Alzheimer’s disease (AD) and the specific factors affecting adverse events of the skin. Methods A 6-month, open labeled, multi-centered, observational study was carried out in 440 patients with probable AD from July 2009to September 2010 (NCT01312363). Results A total of 25.9% of the patients experienced adverse skin events at the rivastigmine patch application site and 17.0% discontinuedtreatment due to adverse events at the skin application site. The most common adverse events were itching and erythema. Patients with an allergichistory and users of electric heating appliances reported skin discomfort. Older age was associated with discontinuing treatment. Conclusions These results suggest that the rivastigmine patch induced some adverse skin events and may contribute to understanding andimproving skin tolerability to the rivastigmine patch.
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