신생아 지속 폐동맥 고혈압에서 흡입 일산화질소 치료의 임상적 적용Clinical Application of Inhaled Nitric Oxide Therapy in Persistent Pulmonary Hypertension of the Newborn
- Other Titles
- Clinical Application of Inhaled Nitric Oxide Therapy in Persistent Pulmonary Hypertension of the Newborn
- Authors
- 이은희; 최병민
- Issue Date
- 2015
- Publisher
- 대한신생아학회
- Keywords
- Nitric oxide inhalation; Newborn; Clinical practice; Persistent fetal circulation syndrome
- Citation
- Neonatal medicine, v.22, no.2, pp.61 - 70
- Indexed
- KCI
- Journal Title
- Neonatal medicine
- Volume
- 22
- Number
- 2
- Start Page
- 61
- End Page
- 70
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/95051
- ISSN
- 2287-9412
- Abstract
- Inhaled nitric oxide (iNO) is recognized as a potent and selective pulmonary vasodilator that does not decrease systemic vascular tone. The therapeutic application of iNO in human was first described in 1991. Subsequent reports showed that iNO therapy was effective to improve oxygenation in infants with persistent pulmonary hypertension of the newborn (PPHN). Owing to its selective pulmonary vasodilator effects, iNO therapy is an important treatment for term newborns with hypoxemic respiratory failure due to PPHN. The Food and Drug Administration of the United States of America first approved iNO in 1999 for use as a medical gas to treat hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in term and late preterm neonates. Thereafter, iNO therapy is clinically applied to treat PPHN in term and late preterm neonates without consensus.
In this review, we focused on the clinical practice of iNO therapy in PPHN. Based on published studies, we discuss iNO initiation and withdrawal methods, respiratory support devices that complement iNO therapy, and the patient and gas monitoring during iNO therapy.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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