Cell Death and Proliferation after Treatment and Reinfection of Clonorchis sinensis in the Sprague-Dawley Rat Bile Duct
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민병훈 | - |
dc.contributor.author | 안가영 | - |
dc.contributor.author | 이형숙 | - |
dc.contributor.author | 김수진 | - |
dc.contributor.author | 주경환 | - |
dc.date.accessioned | 2021-09-04T21:45:41Z | - |
dc.date.available | 2021-09-04T21:45:41Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2287-5123 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/95239 | - |
dc.description.abstract | The structural change and distribution of mitochondrial enzyme (ATPase, cytochrome-c-oxidase), cell proliferation (proliferating cell nuclear antigen, PCNA), cell death (caspase-3) and cell growth factor (fibroblast growth factor 8, FGF-8) in the Sprague-Dawley rat bile duct during Clonorchis sinensis infection was investigated. Experimental groups were divided into C. sinensis infection, superinfection and reinfection of C. sinensis after ‘praziquantel’ treatment group. As a result, C. sinensis infected rat bile ducts showed the features of chronic clonorchiasis, i.e., connective tissue thickening, ductal ἀbrosis and epithelial tissue dilatation. PCNA for cell proliferation increased in the infection group, and decreased after praziquantel treatment. Caspase-3 was distributed in reinfection group only. FGF-8 was distributed in the rat bile duct after praziquantel treatment but not distributed in infection and reinfection group. Overall, C. sinensis infection causes physical and chemical irritations and then brings on the abnormalities of intracellular energy metabolism and cellular growth factors, which hinders bile duct tissue from functioning properly, and resultingly, fibrosis occurs and epithelial cells dilated abnormally. More intense infection makes tissue ἀbrosis chronical and activates apoptosis factors. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 한국현미경학회 | - |
dc.title | Cell Death and Proliferation after Treatment and Reinfection of Clonorchis sinensis in the Sprague-Dawley Rat Bile Duct | - |
dc.title.alternative | Cell Death and Proliferation after Treatment and Reinfection of Clonorchis sinensis in the Sprague-Dawley Rat Bile Duct | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 주경환 | - |
dc.identifier.bibliographicCitation | 한국현미경학회지, v.45, no.2, pp.80 - 88 | - |
dc.relation.isPartOf | 한국현미경학회지 | - |
dc.citation.title | 한국현미경학회지 | - |
dc.citation.volume | 45 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 80 | - |
dc.citation.endPage | 88 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002011084 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Clonorchis sinensis | - |
dc.subject.keywordAuthor | Clonorchiasis | - |
dc.subject.keywordAuthor | Re-epithelialization | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.