MR Imaging Findings of Tamoxifenassociated Uterine Adenosarcoma: Report of Two Cases

Abstract

Adenosarcoma of the uterus is a rare biphasic tumor containing benign glandularepithelial and malignant mesenchymal components. The tumor has been reportedto be associated with antiestrogen therapy, particularly tamoxifen, but there havebeen a few case reports with MRI. We present two cases of MRI findings of uterineadenosarcoma after antiestrogen therapy, tamoxifen and toremifene in breast cancerpatients. The tumor presents as a large polypoid mass occupying the endometrialcavity, and may protrude into the vagina. On MRI, the tumor typically shows solidcomponents with scattered small cysts and heterogeneous enhancement. Thesefindings are not significantly different from conventional adenosarcoma.