Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins
DC Field | Value | Language |
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dc.contributor.author | Joo, N.S. | - |
dc.contributor.author | Evans, I.A.T. | - |
dc.contributor.author | Cho, H.-J. | - |
dc.contributor.author | Park, I.-H. | - |
dc.contributor.author | Engelhardt, J.F. | - |
dc.contributor.author | Wine, J.J. | - |
dc.date.accessioned | 2021-09-04T23:54:41Z | - |
dc.date.available | 2021-09-04T23:54:41Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/95907 | - |
dc.description.abstract | Airway submucosal glands contribute to innate immunity and protect the lungs by secreting mucus, which is required for mucociliary clearance and which also contains antimicrobial, anti-inflammatory, anti-proteolytic and anti-oxidant proteins. We stimulated glands in tracheal trimmings from three lung donors and collected droplets of uncontaminated mucus as they formed at the gland orifices under an oil layer. We analyzed the mucus using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Analysis identified 5486 peptides and 441 proteins from across the 3 samples (269-319 proteins per subject).We focused on 269 proteins common to at least 2 0f 3 subjects, of which 102 (38%) had protective or innate immunity functions. While many of these have long been known to play such roles, for many others their cellular protective functions have only recently been appreciated in addition to their well-studied biologic functions (e.g. annexins, apolipoproteins, gelsolin, hemoglobin, histones, keratins, and lumican). A minority of the identified proteins are known to be secreted via conventional exocytosis, suggesting that glandular secretion occurs via multiplemechanisms. Two of the observed protective proteins, major vault protein and prohibitin, have not been observed in fluid fromhuman epithelial cultures or in fluid fromnasal or bronchoalveolar lavage. Further proteomic analysis of pure gland mucus may help clarify how healthy airways maintain a sterile environment. © 2015 Joo et al. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Public Library of Science | - |
dc.subject | annexin | - |
dc.subject | apolipoprotein | - |
dc.subject | gelsolin | - |
dc.subject | hemoglobin | - |
dc.subject | histone | - |
dc.subject | keratin | - |
dc.subject | lumican | - |
dc.subject | lung resistance protein | - |
dc.subject | prohibitin | - |
dc.subject | airway submucosal gland | - |
dc.subject | Article | - |
dc.subject | cell culture | - |
dc.subject | cell protection | - |
dc.subject | chemical modification | - |
dc.subject | concentration (parameters) | - |
dc.subject | exocytosis | - |
dc.subject | human | - |
dc.subject | human cell | - |
dc.subject | human tissue | - |
dc.subject | innate immunity | - |
dc.subject | liquid chromatography | - |
dc.subject | lung alveolus epithelium | - |
dc.subject | lung lavage | - |
dc.subject | lung protection | - |
dc.subject | mucus secretion | - |
dc.subject | nasal lavage | - |
dc.subject | oxidation | - |
dc.subject | protection | - |
dc.subject | protein analysis | - |
dc.subject | protein function | - |
dc.subject | protein secretion | - |
dc.subject | proteomics | - |
dc.subject | respiratory system | - |
dc.subject | room temperature | - |
dc.subject | tandem mass spectrometry | - |
dc.subject | trachea mucus | - |
dc.subject | metabolism | - |
dc.subject | mucociliary clearance | - |
dc.subject | mucus | - |
dc.subject | proteomics | - |
dc.subject | respiratory system | - |
dc.subject | respiratory tract mucosa | - |
dc.subject | Humans | - |
dc.subject | Mucociliary Clearance | - |
dc.subject | Mucus | - |
dc.subject | Proteomics | - |
dc.subject | Respiratory Mucosa | - |
dc.subject | Respiratory System | - |
dc.title | Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, I.-H. | - |
dc.identifier.doi | 10.1371/journal.pone.0116756 | - |
dc.identifier.scopusid | 2-s2.0-84923781399 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.10, no.2 | - |
dc.relation.isPartOf | PLoS ONE | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | annexin | - |
dc.subject.keywordPlus | apolipoprotein | - |
dc.subject.keywordPlus | gelsolin | - |
dc.subject.keywordPlus | hemoglobin | - |
dc.subject.keywordPlus | histone | - |
dc.subject.keywordPlus | keratin | - |
dc.subject.keywordPlus | lumican | - |
dc.subject.keywordPlus | lung resistance protein | - |
dc.subject.keywordPlus | prohibitin | - |
dc.subject.keywordPlus | airway submucosal gland | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | cell culture | - |
dc.subject.keywordPlus | cell protection | - |
dc.subject.keywordPlus | chemical modification | - |
dc.subject.keywordPlus | concentration (parameters) | - |
dc.subject.keywordPlus | exocytosis | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | human tissue | - |
dc.subject.keywordPlus | innate immunity | - |
dc.subject.keywordPlus | liquid chromatography | - |
dc.subject.keywordPlus | lung alveolus epithelium | - |
dc.subject.keywordPlus | lung lavage | - |
dc.subject.keywordPlus | lung protection | - |
dc.subject.keywordPlus | mucus secretion | - |
dc.subject.keywordPlus | nasal lavage | - |
dc.subject.keywordPlus | oxidation | - |
dc.subject.keywordPlus | protection | - |
dc.subject.keywordPlus | protein analysis | - |
dc.subject.keywordPlus | protein function | - |
dc.subject.keywordPlus | protein secretion | - |
dc.subject.keywordPlus | proteomics | - |
dc.subject.keywordPlus | respiratory system | - |
dc.subject.keywordPlus | room temperature | - |
dc.subject.keywordPlus | tandem mass spectrometry | - |
dc.subject.keywordPlus | trachea mucus | - |
dc.subject.keywordPlus | metabolism | - |
dc.subject.keywordPlus | mucociliary clearance | - |
dc.subject.keywordPlus | mucus | - |
dc.subject.keywordPlus | proteomics | - |
dc.subject.keywordPlus | respiratory system | - |
dc.subject.keywordPlus | respiratory tract mucosa | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Mucociliary Clearance | - |
dc.subject.keywordPlus | Mucus | - |
dc.subject.keywordPlus | Proteomics | - |
dc.subject.keywordPlus | Respiratory Mucosa | - |
dc.subject.keywordPlus | Respiratory System | - |
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