TNF-alpha-308 A/G and-238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis

Abstract

The purpose of this study was to examine whether tumor necrosis factor-alpha (TNF-alpha) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted examining the association between TNF-alpha -308 A/G and -238 A/G polymorphisms and glaucoma. A total of 13 studies on TNF-alpha -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The meta-analysis revealed no association between the TNF-alpha -308 A allele and glaucoma [odds ratio (OR) = 1.403, 95% confidence interval (CI) = 0.784-2.513, P = 0.254]. Subgroup analysis by disease type revealed no association between the TNF-alpha -308 A allele and glaucoma. The meta-analysis revealed no significant association between the TNF-alpha -238 A allele and glaucoma (OR = 1.120, 95% CI = 0.708-1.773, P = 0.628). This meta-analysis showed no association between the A alleles of the TNF-alpha -308 A/G or -238 A/G polymorphisms and glaucoma.