Recent development of biotin conjugation in biological imaging, sensing, and target delivery
- Authors
- Ren, Wen Xiu; Han, Jiyou; Uhm, Soojin; Jang, Yu Jin; Kang, Chulhun; Kim, Jong-Hoon; Kim, Jong Seung
- Issue Date
- 2015
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.51, no.52, pp.10403 - 10418
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 51
- Number
- 52
- Start Page
- 10403
- End Page
- 10418
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/96134
- DOI
- 10.1039/c5cc03075g
- ISSN
- 1359-7345
- Abstract
- Despite encouraging results from preliminary studies of anticancer therapies, the lack of tumor specificity remains an important issue in the modern pharmaceutical industry. New findings indicate that biotin or biotin-conjugates could be favorably assimilated by tumor cells that over-express biotin-selective transporters. Furthermore, biotin can form stable complexes with avidin and its bacterial counterpart streptavidin. The strong bridging between avidin and biotin moieties on other molecules is a proven adaptable tool with broad biological applications. Under these circumstances, a biotin moiety is certainly an attractive choice for live-cell imaging, biosensing, and target delivery.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
- College of Science > Department of Chemistry > 1. Journal Articles
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