Associations between TNF-alpha polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Bae, S. C. | - |
dc.date.accessioned | 2021-09-05T00:46:50Z | - |
dc.date.available | 2021-09-05T00:46:50Z | - |
dc.date.created | 2021-06-15 | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1676-5680 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/96137 | - |
dc.description.abstract | We investigated whether the tumor necrosis factor-alpha (TNF-alpha) promoter -238 A/G and -308 A/G polymorphisms are associated with rheumatoid arthritis (RA) and vitiligo susceptibility. MEDLINE and EMBASE databases and a manual search were used to identify articles in which TNF-alpha polymorphisms were determined in RA or vitiligo patients and controls. Meta-analysis was used to examine the associations between the TNF-alpha -238 A/G polymorphism and RA and vitiligo using the allelic contrast and dominant models. Fifteen studies (10 RA and 5 vitiligo) involving 3678 cases and 4400 controls were considered. We observed an association between the TNF-alpha -238 A allele and RA when all subjects were considered [odds ratio (OR) = 0.686, 95% confidence interval (CI) = 0.476-0.968, P = 0.043]. After stratification by ethnicity, we found no association between the TNF-alpha -238 A allele and RA in European or Asian populations. We observed no association between the TNF-alpha -308 A allele and vitiligo (OR = 1.787, 95% CI = 0.894-3.573, P = 0.101). However, the adjusted OR by the trim-and-fill technique was significant (OR = 2.064, 95%CI = 1.138-3.743). After stratification by geographic continent, the TNF-alpha -308 A allele was significantly associated with vitiligo in Middle Eastern populations (OR = 1.569, 95%CI = 1.224-2.013, P = 3.8 x 10(-5)). The TNF-alpha -238 A/G polymorphism was associated with RA susceptibility, and the TNF-alpha -308 A/G polymorphism may be a significant risk factor for vitiligo in Middle Eastern populations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FUNPEC-EDITORA | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | PROMOTER-308 A/G POLYMORPHISM | - |
dc.subject | DISEASE | - |
dc.subject | GENE | - |
dc.subject | POPULATION | - |
dc.subject | SEVERITY | - |
dc.subject | CYTOKINE | - |
dc.title | Associations between TNF-alpha polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.4238/2015.May.25.6 | - |
dc.identifier.scopusid | 2-s2.0-84930009730 | - |
dc.identifier.wosid | 000357183700281 | - |
dc.identifier.bibliographicCitation | GENETICS AND MOLECULAR RESEARCH, v.14, no.2, pp.5548 - 5559 | - |
dc.relation.isPartOf | GENETICS AND MOLECULAR RESEARCH | - |
dc.citation.title | GENETICS AND MOLECULAR RESEARCH | - |
dc.citation.volume | 14 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 5548 | - |
dc.citation.endPage | 5559 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | PROMOTER-308 A/G POLYMORPHISM | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | SEVERITY | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Tumor necrosis factor | - |
dc.subject.keywordAuthor | Vitiligo | - |
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