Associations between interleukin-1 and IL-1 receptor antagonist polymorphisms and susceptibility to rheumatoid arthritis: A meta-analysis
- Authors
- Lee, Y. H.; Bae, S-C.
- Issue Date
- 2015
- Publisher
- C M B ASSOC
- Keywords
- Rheumatoid arthritis; Interleukin-1; Polymorphism; Meta-analysis
- Citation
- CELLULAR AND MOLECULAR BIOLOGY, v.61, no.8, pp.105 - 111
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLULAR AND MOLECULAR BIOLOGY
- Volume
- 61
- Number
- 8
- Start Page
- 105
- End Page
- 111
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/96159
- ISSN
- 0145-5680
- Abstract
- This study determined whether interleukin-1 (IL-1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between the IL-1A, IL-1B, and IL-1 receptor antagonist (IL-1RN) polymorphisms and RA. A total of 16 studies involving 4,339 RA cases and 3,885 controls were included in the meta-analysis. Meta-analysis of the IL-1B -511 C/T polymorphism revealed an association between the IL-1B -511 T allele and RA in Caucasians (OR = 0.913, 95% CI = 0.840-0.992, p = 0.031), but not in Asians. Ethnicity-specific meta-analysis indicated an association between the TT+TC genotype of the IL-1B 3953 C/T polymorphism and RA in Caucasians (OR = 1.243, 95% CI = 1.008-1.533, p = 0.042) and in Asians (OR = 2.672, 95% CI = 1.662-4.296, p = 4.9x10(-6)). No association was between RA susceptibility and the IL-1A -889 C/T, IL-1A + 4845 G/T, and IL-1RN + 2018 C/T polymorphisms. This meta-analysis suggests the IL-1B -511 C/T polymorphism is associated with susceptibility to RA in Caucasians, and that the IL-1B + 3953 C/T polymorphism is associated with susceptibility to RA in Caucasians and Asians.
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