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Biotin-guided anticancer drug delivery with acidity-triggered drug release
- Park, Soyeon;
- Kim, Eunjin;
- Kim, Won Young;
- Kang, Chulhun;
- Kim, Jong Seung
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77초록
A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.
키워드
MESOPOROUS SILICA NANOPARTICLES; PH; PRODRUG; TUMORS
- 제목
- Biotin-guided anticancer drug delivery with acidity-triggered drug release
- 저자
- Park, Soyeon; Kim, Eunjin; Kim, Won Young; Kang, Chulhun; Kim, Jong Seung
- 발행일
- 2015
- 유형
- Article
- 권
- 51
- 호
- 45
- 페이지
- 9343 ~ 9345