Association between functional CD24 polymorphisms and susceptibility to autoimmune diseases: A meta-analysis
- Authors
- Lee, Y. H.; Bae, S-C.
- Issue Date
- 2015
- Publisher
- C M B ASSOC
- Keywords
- Autoimmune diseases; CD24; Polymorphism; Meta-analysis
- Citation
- CELLULAR AND MOLECULAR BIOLOGY, v.61, no.8, pp.97 - 104
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLULAR AND MOLECULAR BIOLOGY
- Volume
- 61
- Number
- 8
- Start Page
- 97
- End Page
- 104
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/96201
- ISSN
- 0145-5680
- Abstract
- This study aimed to explore whether the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to autoimmune diseases. A meta-analysis was conducted on the associations between the CD24 A57V and TG/del polymorphisms and autoimmune diseases using (1) allele contrast, and (2) the recessive, (3) dominant, and (4) co-dominant models. Twenty-six comparative studies with 7,507 patients and 8,803 controls were included in the meta-analysis. The meta-analysis revealed a significant association between autoimmune disease and the CD24 Val allele (OR = 1.285, 95% CI = 1.177-1.403, p = 1.0 x 10(-9)). Meta-analysis by autoimmune disease type showed a significant association between the CD24 Val allele and multiple sclerosis (MS) (OR = 1.420, 95% CI = 1.239-1.628, p = 4.7 x 10(-8)) and systemic lupus erythematous (SLE) (OR = 1.282, 95% CI = 1.081-1.521, p = 0.004), but not Crohn's disease (CD) (OR = 1.003, 95% CI = 0.826-1.218, p = 0.974). Meta-analysis of the CD24 Val/Val genotype showed an association with ulcerative colitis (OR = 1.778, 95% CI = 1.148-2.753, p = 0.010). In addition, meta-analysis by autoimmune disease type revealed a significant association between the CD24 TG-deletion allele and MS (OR = 0.596, 95% CI = 0.415-0.856, p = 0.005) and CD (OR = 1.594, 95% CI = 1.175-2.161, p = 0.003). This meta-analysis indicates that the functional CD24 A57V and TG/del polymorphisms are associated with susceptibility to multiple autoimmune diseases including SLE, MS, UC and CD.
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