Divalent metal ion-mediated assembly of spherical nucleic acids: the case study of Cu2+
- Authors
- Joo, Jang Ho; Lee, Jae-Seung
- Issue Date
- 2015
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- PHYSICAL CHEMISTRY CHEMICAL PHYSICS, v.17, no.45, pp.30292 - 30299
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Volume
- 17
- Number
- 45
- Start Page
- 30292
- End Page
- 30299
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/96259
- DOI
- 10.1039/c5cp05202e
- ISSN
- 1463-9076
- Abstract
- Despite the critical functions of divalent metal ions (M2+ s) in association with duplex DNA, fundamental and general interactions of M2+ s with spherical nucleic acids (SNAs) composed of single-stranded DNA have rarely been investigated. We have explored that the coordinative nature of the M2+-SNA binding mediates the temperature-and base composition-dependent reversible assemblies of SNAs even without the need of complementary counterparts for duplex-interconnection, additional monovalent metal ions for charge screening, or pre-designed sequences for any non-Watson-Crick base-pairing, all of which are essential for the conventional assembly of SNAs. Cu2+ has been identified to maximize the reversible assembly properties in relation to this M2+-mediated DNA bond, and has been further qualitatively and quantitatively investigated in detail as a model system.
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Collections - College of Engineering > Department of Materials Science and Engineering > 1. Journal Articles
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